Skip to main content

Archived Comments for: Changes of blood biochemistry in the rabbit animal model in atherosclerosis research; a time- or stress-effect

Back to article

  1. CEO-PhD

    Halina Malina, MalinaLab-Axanton

    5 January 2012

    It is a model of anesthetic product toxicity?

    In the title of the article is a lack of the most significant factors, which probably are responsible for the observed changes, the anesthetic products.
    It could be a particularly suitable model for the toxicity of the anesthetic products and frequency of their use.
    The rabbits were anaesthetized 3 times with 12 mg/kg every month. The third anesthesia did not account for metabolic changes, because they were killed. However, they live for three months after the treatment of anesthetic products (final 72 mg of ketamine per rabbit, 3 kg).
    Excellent results showing, how frequency of anesthesia and the use of a small molecule, which lead to protein modification, results in pathology.
    There is a lack of information about diet. The source of the proteins in the diet is important.

    Competing interests

    Malina H. or Malina H.Z. Patents

Advertisement