The predominant isotype of oxLDL antibodies isolated either from serum (free antibodies) or precipitated soluble immune complexes (antigen-associated antibodies) is IgG of subclasses 1 and 3 . At present, oxLDL antibodies have not yet become biomarkers for the development and/or progression of atherosclerosis . Positive correlation between the levels of oxLDL-lgG antibodies and different endpoints considered as evidence of atherosclerotic vascular disease has been reported by many studies . The protective role of IgM oxLDL antibodies has been proposed in human cardiovascular diseases .
In the present study, there were significantly lower serum levels of TC, HDL-c, and ADP in the AML group than that in the control group. The results were similar to those of a previous research [1–3, 5].
The main finding of the present study was the descensive oxLDL-lgG and elevated oxLDL-lgM serum levels in patients with AML compared with normal controls after controlled potential confounders by the covariance analysis model. Logistic regression analysis revealed that lower oxLDL-lgG serum levels predict decreased risk of AML. However, higher oxLDL-lgM serum levels predict increased risk of AML. In contrast, there were both elevated oxLDL-lgG and descensive oxLDL-lgM serum levels in patients with cardiovascular or cerebrovascular diseases in the reported literature .
In recent years, there has been a growing body of evidence that excessive lipid peroxidation, including oxLDL and anti-oxLDL autoantibodies, which reflect in the indicators of oxidative stress in vivo, may play a key role in cancer development [9, 10].
In this study, only selected adult AML patients were used as subjects. Lymphocytic leukemia and other blood diseases were ruled out, and the misclassification error does not exist. In the experimental determination of indicators, less than 10% coefficient of variation was the quality control. There were correlations between TC, TG, HDL, and LDL, resulting in a collinearity in the linear regression analysis. Consequently, a covariance of analysis was used in the study. Therefore, the results of this study are not biased.