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  1. Research

    Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway

    Nonalcoholic fatty liver disease is one of the most common liver diseases in the world and is a typical hepatic manifestation of metabolic syndrome which is characterized with lipid accumulation in liver. Nico...

    Ling-Fang Wang, Xiao-Nv Wang, Cong-Cong Huang, Long Hu, Yun-Fei Xiao, Xiao-Hui Guan, Yi-Song Qian, Ke-Yu Deng and Hong-Bo Xin

    Lipids in Health and Disease 2017 16:82

    Published on: 27 April 2017

  2. Research

    Enhanced status of inflammation and endothelial activation in subjects with familial hypercholesterolaemia and their related unaffected family members: a case control study

    Familial hypercholesterolaemia (FH) leads to premature coronary artery diseases (CAD) which pathophysiologically can be measured by inflammation, endothelial activation and oxidative stress status. However, th...

    Thuhairah Rahman, Nur Suhana Hamzan, Atiqah Mokhsin, Radzi Rahmat, Zubin Othman Ibrahim, Rafezah Razali, Malathi Thevarajah and Hapizah Nawawi

    Lipids in Health and Disease 2017 16:81

    Published on: 24 April 2017

  3. Research

    PPBP and DEFA1/DEFA3 genes in hyperlipidaemia as feasible synergistic inflammatory biomarkers for coronary heart disease

    Coronary heart disease (CHD) is an important complication of atherosclerosis. Biomarkers, which associate with CHD development, are potential to predict CHD risk. To determine whether genes showing altered exp...

    Yaowapa Maneerat, Kriengchai Prasongsukarn, Surachet Benjathummarak and Wilanee Dechkhajorn

    Lipids in Health and Disease 2017 16:80

    Published on: 19 April 2017

  4. Research

    Prevalence of overweight and obesity among police officers in Riyadh City and risk factors for cardiovascular disease

    Despite the prevalence of overweight and obesity and increases in associated diseases such as diabetes and heart disease in the Saudi population, no studies have addressed the spread of obesity among Saudi pol...

    Abdullah S. Alghamdi, Mohammed A. Yahya, Ghedeir M. Alshammari and Magdi A. Osman

    Lipids in Health and Disease 2017 16:79

    Published on: 14 April 2017

  5. Research

    Milk protein-based formulas containing different oils affect fatty acids balance in term infants: A randomized blinded crossover clinical trial

    Palm olein is used in infant formula fat blends in order to match the fatty acid profile of human milk. While the effects on fatty acid balance have been evaluated, the use of palm olein in combination with pa...

    Carolina Oliveira de Souza, Maria Efigênia Q. Leite, John Lasekan, Geraldine Baggs, Lorena Silva Pinho, Janice Izabel Druzian, Tereza Cristina M. Ribeiro, Ângela P. Mattos, José A. Menezes-Filho and Hugo Costa-Ribeiro

    Lipids in Health and Disease 2017 16:78

    Published on: 14 April 2017

  6. Research

    A comparison of effects of DPP-4 inhibitor and SGLT2 inhibitor on lipid profile in patients with type 2 diabetes

    Previous studies suggest that dipeptidyl peptidase-4 (DPP-4) inhibitors and sodium glucose cotransporter 2 (SGLT2) inhibitors have different effects on the lipid profile in patients with type 2 diabetes. We in...

    Seon-Ah Cha, Yong-Moon Park, Jae-Seung Yun, Tae-Seok Lim, Ki-Ho Song, Ki-Dong Yoo, Yu-Bae Ahn and Seung-Hyun Ko

    Lipids in Health and Disease 2017 16:58

    Published on: 13 April 2017

  7. Research

    Lipids bearing extruded-spheronized pellets for extended release of poorly soluble antiemetic agent—Meclizine HCl

    Antiemetic agent Meclizine HCl, widely prescribed in vertigo, is available only in immediate release dosage forms. The approved therapeutic dose and shorter elimination half-life make Meclizine HCl a potential...

    Faaiza Qazi, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Muhammad Iqbal Nasiri, Kamran Ahmed and Mansoor Ahmad

    Lipids in Health and Disease 2017 16:75

    Published on: 12 April 2017

  8. Research

    Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia

    Sickle cell anemia (SCA) patients exhibit sub-phenotypes associated to hemolysis and vaso-occlusion. The disease has a chronic inflammatory nature that has been also associated to alterations in the lipid prof...

    Milena Magalhães Aleluia, Caroline Conceição da Guarda, Rayra Pereira Santiago, Teresa Cristina Cardoso Fonseca, Fábia Idalina Neves, Regiana Quinto de Souza, Larissa Alves Farias, Felipe Araújo Pimenta, Luciana Magalhães Fiuza, Thassila Nogueira Pitanga, Júnia Raquel Dutra Ferreira, Elisângela Vitória Adorno, Bruno Antônio Veloso Cerqueira and Marilda de Souza Gonçalves

    Lipids in Health and Disease 2017 16:74

    Published on: 11 April 2017

  9. Research

    Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice

    Eicosapentaenoic acid (EPA, C20:5n-3), docosahexaenoic acid (DHA, C22:6n-3) and arachidonic acid (AA, C20:4n-6) are long-chain polyunsaturated fatty acids (LCPUFAs) with relevant roles in the organism. EPA and...

    Rodrigo Valenzuela, Francisca Echeverria, Macarena Ortiz, Miguel Ángel Rincón-Cervera, Alejandra Espinosa, María Catalina Hernandez-Rodas, Paola Illesca, Alfonso Valenzuela and Luis A. Videla

    Lipids in Health and Disease 2017 16:64

    Published on: 11 April 2017

  10. Research

    Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for the diagnosis of the oral squamous cell carcinoma

    Oral squamous cell carcinoma (OSCC) is becoming more common across the globe. The prognosis of OSCC is largely dependent on the early detection. But the routine oral cavity examination may delay the diagnosis ...

    Yingyun Tan, Bing Yan, Lili Xue, Yi Li, Xianyang Luo and Ping Ji

    Lipids in Health and Disease 2017 16:73

    Published on: 7 April 2017

  11. Hypothesis

    Estrogen lowers triglyceride via regulating hepatic APOA5 expression

    Estrogen had been found to be negatively associated with serum triglyceride (TG) levels. Apolipoprotein A5 (APOA5), a novel member of apolipoprotein family, was reported to have a strong ability to decrease se...

    Fei Luo, Yuan Guo, Gui-yun Ruan, Ran Peng and Xiang-ping Li

    Lipids in Health and Disease 2017 16:72

    Published on: 4 April 2017

  12. Research

    Fatty acid composition in serum cholesterol esters and phospholipids is linked to visceral and subcutaneous adipose tissue content in elderly individuals: a cross-sectional study

    Visceral adipose tissue (VAT) and truncal fat predict cardiometabolic disease. Intervention trials suggest that saturated fatty acids (SFA), e.g. palmitic acid, promote abdominal and liver fat storage whereas ...

    Fredrik Rosqvist, Helena Bjermo, Joel Kullberg, Lars Johansson, Karl Michaëlsson, Håkan Ahlström, Lars Lind and Ulf Risérus

    Lipids in Health and Disease 2017 16:68

    Published on: 4 April 2017

  13. Research

    New association of bone morphogenetic protein 4 concentrations with fat distribution in obesity and Exenatide intervention on it

    Bone morphogenetic protein 4 (BMP-4) has been proven to regulate white adipogensis. We aimed to demonstrate the correlation of BMP-4 with fat distribution and Exenatide treatment on it.

    Xingchun Wang, Jiaqi Chen, Liang Li, Cui Ling Zhu, Jingyang Gao, Sharvan Rampersad, Le Bu and Shen Qu

    Lipids in Health and Disease 2017 16:70

    Published on: 4 April 2017

  14. Research

    17β-estradiol regulates the expression of apolipoprotein M through estrogen receptor α-specific binding motif in its promoter

    We have previously demonstrated that estrogen could significantly enhance expression of apolipoprotein M (apoM), whereas the molecular basis of its mechanism is not fully elucidated yet. To further investigate...

    Jiang Wei, Yang Yu, Guang-hua Luo, Yue-hua Feng, Yuan-ping Shi, Jun Zhang, Qin-feng Mu, Miao-mei Yu, Li-li Pan, Maria Berggren-Söderlund, Peter Nilsson-Ehle, Xiao-ying Zhang and Ning Xu

    Lipids in Health and Disease 2017 16:66

    Published on: 31 March 2017

  15. Research

    A Single Nucleotide Polymorphism in the FADS1 Gene is Associated with Plasma Fatty Acid and Lipid Profiles and Might Explain Gender Difference in Body Fat Distribution

    Genotyping of the rs174547 polymorphism in the fatty acid desaturase 1 gene (FADS1) shows that it is associated with the FA composition of plasma phospholipids and lipid metabolic indices among several ethnic gro...

    Huilan Guo, Lichao Zhang, Chaonan Zhu, Fei Yang, Shanshan Wang, Shankuan Zhu and Xiaoguang Ma

    Lipids in Health and Disease 2017 16:67

    Published on: 31 March 2017

  16. Research

    Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice

    A sedentary lifestyle and poor diet are risk factors for the progression of non-alcoholic fatty liver disease. However, the pathogenesis of hepatic lipid accumulation is not completely understood. Therefore, t...

    Tingting Shang, Liang Liu, Jia Zhou, Mingzhen Zhang, Qinling Hu, Min Fang, Yongning Wu, Ping Yao and Zhiyong Gong

    Lipids in Health and Disease 2017 16:65

    Published on: 29 March 2017

  17. Research

    Hypercholesterolemia downregulates autophagy in the rat heart

    We have previously shown that efficiency of ischemic conditioning is diminished in hypercholesterolemia and that autophagy is necessary for cardioprotection. However, it is unknown whether isolated hypercholes...

    Zoltán Giricz, Gábor Koncsos, Tomáš Rajtík, Zoltán V. Varga, Tamás Baranyai, Csaba Csonka, Adrián Szobi, Adriana Adameová, Roberta A. Gottlieb and Péter Ferdinandy

    Lipids in Health and Disease 2017 16:60

    Published on: 23 March 2017

  18. Research

    Risk factors of atherosclerotic tissue types in single-vessel and intermediate coronary lesions: a cross-sectional study

    Few data exist that correlate lesion-related risk factors such as conventional cardiovascular risks or lipoprotein-associated phospholipase A2 (Lp-PLA2) with tissue types within atherosclerotic plaques in pati...

    Xianjin Wang, Qun Chen, Yu Xu, Yanqing Wang, Yang Yang, Ming Gu, Haihua Xu and Yanfang Zhao

    Lipids in Health and Disease 2017 16:63

    Published on: 23 March 2017

  19. Research

    The prevalence, awareness, treatment, and control of dyslipidemia in northeast China: a population-based cross-sectional survey

    Dyslipidemia is an important independent modifiable risk factor for cardiovascular disease. The aim of this study was to explore the current prevalence, awareness, treatment and control of dyslipidemia and its...

    Fu-Liang Zhang, Ying-Qi Xing, Yan-Hua Wu, Hao-Yuan Liu, Yun Luo, Ming-Shuo Sun, Zhen-Ni Guo and Yi Yang

    Lipids in Health and Disease 2017 16:61

    Published on: 23 March 2017

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