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Table 1 Kinetic Constants of the AEA Membrane Transporter (AMT) in Brain Synaptosomes and Inhibition by Glutamine and Glutamate

From: Anandamide uptake by synaptosomes from human, mouse and rat brain: inhibition by glutamine and glutamate

Kinetic constant Human Meningioma Mouse Brain Rat Brain
Km (nM) 793 ± 128 660 ± 80 483 ± 52
Vmax (pmol/min per mg protein) 219 ± 19 370 ± 23 357 ± 18
Ki of L-Glutamine (nM)a 1100 ± 90 970 ± 80 850 ± 80
Ki of D-Glutamine (nM)a 525 ± 50 480 ± 50 430 ± 45
Ki of L-Glutamate (nM)a 4000 ± 370 3580 ± 300 3300 ± 310
Ki of D-Glutamate (nM)a 1230 ± 110 1100 ± 90 850 ± 80
  1. aNon-competitive inhibitor of AMT in all cases.