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Table 1 Genes upregulated by oxLDL in polarized macrophages

From: Different responses to oxidized low-density lipoproteins in human polarized macrophages

The top 30 genes upregulated by oxLDL in M0

Gene Symbol

Ref Seq ID

M0

M1

M2

NCBI official full name

IL8

NM_000584

6.200

3.200

5.177

interleukin 8

CCL1

NM_002981

6.028

0.937

-

chemokine (C-C motif) ligand 1

SERPINB2

NM_002575

5.485

-

-

serpin peptidase inhibitor, clade B (ovalbumin), member 2

IL1B

NM_000576

5.162

2.700

2.684

interleukin 1, beta

PTGS2

NM_000963

4.985

-

-

prostaglandin-endoperoxide synthase 2

TM4SF1

NM_014220

4.836

-

1.238

transmembrane 4 L six family member 1

CCL19

NM_006274

4.834

0.368

-

chemokine (C-C motif) ligand 19

POPDC3

NM_022361

4.557

1.491

-

popeye domain containing 3

INHBA

NM_002192

4.476

2.335

-

inhibin, beta A

CKB

NM_001823

4.378

0.920

2.107

creatine kinase, brain

IFIT1

NM_001001887

4.152

0.717

5.734

interferon-induced protein with tetratricopeptide repeats 1

CCL5

NM_002985

4.075

-0.218

1.616

chemokine (C-C motif) ligand 5

IFIT5

NM_012420

4.039

-

-

interferon-induced protein with tetratricopeptide repeats 5

TNFAIP6

NM_007115

4.033

0.019

-

tumor necrosis factor, alpha-induced protein 6

TRIM16

NM_006470

3.990

2.992

3.453

tripartite motif-containing 16

ADM

NM_001124

3.973

4.807

3.202

adrenomedullin

CCL4L2

NM_207007

3.905

1.321

0.448

chemokine (C-C motif) ligand 4-like 2

ISG20

NM_002201

3.839

0.952

4.442

interferon stimulated exonuclease gene 20kDa

EREG

NM_001432

3.726

2.793

-

epiregulin

CSF2

NM_000758

3.644

1.605

0.724

colony stimulating factor 2 (granulocyte-macrophage)

RHOF

NM_019034

3.638

-

3.020

ras homolog gene family, member F (in filopodia)

GSTM3

NM_000849

3.632

2.635

2.543

glutathione S-transferase mu 3 (brain)

AKR1C3

NM_003739

3.497

2.490

3.432

aldo-keto reductase family 1, member C3

CYP7B1

NM_004820

3.482

-

-

cytochrome P450, family 7, subfamily B, polypeptide 1

CCL4

NM_002984

3.466

0.742

-0.123

chemokine (C-C motif) ligand 4

CCL24

NM_002991

3.433

0.413

-

chemokine (C-C motif) ligand 24

NT5E

NM_002526

3.406

-

-

5'-nucleotidase, ecto (CD73)

IFI44L

NM_006820

3.325

-0.074

4.474

interferon-induced protein 44-like

COX11

NM_004375

3.306

1.946

1.111

COX11 cytochrome c oxidase assembly homolog (yeast)

NOL12

NM_024313

3.281

0.937

1.313

nucleolar protein 12

The top 30 genes upregulated by oxLDL in M1

Gene Symbol

Ref Seq ID

M0

M1

M2

NCBI official full name

ADM

NM_001124

3.973

4.807

3.202

adrenomedullin

S1RT5

NM_012241

3.039

3.486

2.137

sirtuin 5

CXCR5

NM_032966

1.986

3.437

1.815

chemokine (C-X-C motif) receptor 5

KLHL21

NM_014851

2.380

3.324

-

kelch-like 21 (Drosophila)

IL8

NM_000584

6.200

3.200

5.177

interleukin 8

DPYSL3

NM_001387

3.064

3.192

3.497

dihydropyrimidinase-like 3

RAB43

NM_198490

1.264

3.003

3.324

RAB43, member RAS oncogene familyprovided

TRIM16

NM_006470

3.990

2.992

3.453

tripartite motif-containing 16

C1orf66

NM_015997

0.382

2.970

1.953

chromosome 1 open reading frame 66

PIP4K2A

NM_005028

2.325

2.967

3.127

phosphatidylinositol-5-phosphate 4-kinase, type II, alpha

AGAP3

NM_031946

1.289

2.945

1.091

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

INPP4A

NM_001566

0.129

2.872

1.872

inositol polyphosphate-4-phosphatase, type I, 107kDa

DAGLA

NM_006133

1.545

2.834

2.807

diacylglycerol lipase, alpha

EREG

NM_001432

3.726

2.793

-

epiregulin

AGAP11

NM_133447

0.971

2.791

2.318

ankyrin repeat and GTPase domain Arf GTPase activating protein 11

ADAMTS10

NM_030957

0.683

2.773

0.952

ADAM metallopeptidase with thrombospondin type 1 motif, 10

KCP

NM_199349

1.269

2.746

1.861

kielin/chordin-like protein

ZFAT

NM_020863

1.758

2.743

2.002

zinc finger and AT hook domain containing

LZTR1

NM_006767

1.092

2.714

3.134

leucine-zipper-like transcription regulator 1

MON1B

NM_014940

0.234

2.712

-0.754

MON1 homolog B (yeast)

IL1B

NM_000576

5.162

2.700

2.684

interleukin 1, beta

STAM

NM_003473

-0.222

2.697

-0.150

signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

MAFG

NM_032711

2.775

2.684

2.997

v-maf musculoaponeurotic fibrosarcoma oncogene homologG (avian)

OSGIN1

NM_182981

2.427

2.672

2.002

oxidative stress induced growth inhibitor 1

ZNF673

NM_017776

0.606

2.669

-

zinc finger family member 673

IREB2

NM_004136

-

2.648

-

iron-responsive element binding protein 2

GSTM3

NM_000849

3.632

2.635

2.543

glutathione S-transferase mu 3 (brain)

UBR2

NM_015255

2.160

2.619

2.371

ubiquitin protein ligase E3 component n-recognin 2

SFT2D3

NM_032740

1.146

2.577

1.609

SFT2 domain containing 3

FAM70A

NM_017938

-

2.577

2.614

family with sequence similarity 70, member A

The top 30 genes upregulated by oxLDL in M2

Gene Symbol

Ref Seq ID

M0

M1

M2

NCBI official full name

IFIT2

NM_001547

2.559

-

5.893

interferon-induced protein with tetratricopeptide repeats 2

IFIT1

NM_001001887

4.152

0.717

5.734

interferon-induced protein with tetratricopeptide repeats 1

IL8

NM_000584

6.200

3.200

5.177

interleukin 8

MX2

NM_002463

2.482

0.562

4.552

myxovirus (influenza virus) resistance 2 (mouse)

IFI44L

NM_006820

3.325

-0.074

4.474

interferon-induced protein 44-like

ISG20

NM_002201

3.839

0.952

4.442

interferon stimulated exonuclease gene 20kDa

IDO1

NM_002164

-

0.623

4.335

indoleamine 2,3-dioxygenase 1

PLSCR1

NM_021105

2.002

-0.179

4.119

phospholipid scramblase 1

IFIT3

NM_001549

2.306

-0.483

3.943

interferon-induced protein with tetratricopeptide repeats 3

SGPP2

NM_152386

3.229

-

3.626

sphingosine-1-phosphate phosphatase 2

OR9I1

NM_001005211

2.923

1.683

3.574

olfactory receptor, family 9, subfamily I, member 1

VNN1

NM_004666

0.568

0.896

3.569

vanin 1

DPYSL3

NM_001387

3.064

3.192

3.497

dihydropyrimidinase-like 3

TRIM16

NM_006470

3.990

2.992

3.453

tripartite motif-containing 16

EPSTI1

NM_033255

2.678

-0.642

3.439

epithelial stromal interaction 1 (breast)

AKR1C3

NM_003739

3.497

2.490

3.432

aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

RAB43

NM_198490

1.264

3.003

3.324

RAB43, member RAS oncogene family

APOL6

NM_030641

1.925

0.723

3.291

apolipoprotein L, 6

USP18

NM_017414

1.686

0.052

3.288

ubiquitin specific peptidase 18

ADM

NM_001124

3.973

4.807

3.202

adrenomedullin

RSAD2

NM_080657

1.858

0.083

3.194

radical S-adenosyl methionine domain containing 2

LZTR1

NM_006767

1.092

2.714

3.134

leucine-zipper-like transcription regulator 1

PIP4K2A

NM_005028

2.325

2.967

3.127

phosphatidylinositol-5-phosphate 4-kinase, type II, alpha

CSF2RA

NM_172247

1.683

2.109

3.115

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

TNFRSF9

NM_001561

2.899

1.702

3.100

tumor necrosis factor receptor superfamily, member 9

ARHGAP44

NM_014859

1.136

1.919

3.053

Rho GTPase activating protein 44

RHOF

NM_019034

3.638

-

3.020

ras homolog gene family, member F (in filopodia)

CWF19L1

NM_018294

1.271

2.098

3.005

CWF19-like 1, cell cycle control (S. pombe)

MAFG

NM_032711

2.775

2.684

2.997

v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)

TNFRSF4

NM_003327

1.815

1.376

2.974

tumor necrosis factor receptor superfamily, member 4

  1. Non-polarized (M0) and polarized M1 and M2 macrophages were treated with or without oxLDL for 6 h. The changes in gene expression were analyzed by cDNA microarray analysis as described in the Materials and methods section. The top 30 upregulated genes in each subset of macrophages are listed. The values denote fold changes (log2 ratio) of normalized intensities during oxLDL treatment. Letters in boldface indicate genes that were also upregulated by more than 2-fold in the two other subsets. "-" indicates genes that did not show significantly altered expression. Twenty-eight of the top 30 upregulated genes in M2 macrophages (93% of the top 30 genes) were also upregulated in M0, while 15 genes in the top 30 upregulated genes in M2 macrophages were upregulated in M1 cells.
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Lipids in Health and Disease

ISSN: 1476-511X