From: Different responses to oxidized low-density lipoproteins in human polarized macrophages
Top 5 Networks in M0 | ||||
---|---|---|---|---|
ID | Molecules in Network | Score | Focus Molecules | Top Functions |
#1 | BARX2, CD226, CRABP1, CTH, Cytokeratin, FOLR2, FOS, GCLM, GCNT1, HHEX, HTATIP2, IGDCC3, KCNJ2, KRT8, KRT18, KRT20, KRT6A, LPCAT3, MAF, MAFB, MAFF, MAFG, MT1A, musculoaponeurotic fibrosarcoma oncogene, NFE2L3, NRF1, PAX6, PLAGL1, PVR, S100P, TGFBI, TH1 Cytokine, TLE1, TMSB4, TMSB4X | 33 | 31 | Cellular Assembly and Organization, Cellular Function and Maintenance, Hair and Skin Development and Function |
#2 | Alpha tubulin, APEX2, ARRDC3, CALB2, Calbindin, CSF1, CXORF21, DHCR24, DUB, EHMT2, FAM105A, FAM107A, GSC, HDAC6, HOOK2, LMO2, LRRC58, MIR124, NTRK3, oxidoreductase, POU5F1, PPP1R12C, REST, RYK, STAU1, TRPM2, TSPAN14, Tubulin, USP12, USP28, USP34, USP41, USP48, USP49, ZBED3 | 28 | 29 | Auditory and Vestibular System Development and Function, Genetic Disorder, Metabolic Disease |
#3 | ANAPC1, ANAPC2, ANAPC5, APC, ASNS, BIRC3, CD3EAP, CDC20, CHD2, CKAP2, Cpt, CPT2, Cyclin A, DTYMK, E3 RING, EIF5, GLCE, GPC1, HEXIM1, HGF, IMPDH2, Integrin alpha V beta 3, ISG20, JMJD1C, MYL12A, NAMPT, POLR1A, SLC40A1, SPATC1, SPDEF, TMEM158, TOPBP1, UBR2, Vegf, VHL | 28 | 29 | Protein Degradation, Protein Synthesis, Cardiovascular System Development and Function |
#4 | ALDH2, ASXL1, C14ORF1, CBX4, CCDC106, CDK5RAP2, Cyclooxygenase, DIO3, DUSP8, FHL1, JDP2, LSM2, MIP1, MYBPC3, P38 MAPK, PCGF2, PHYHIP, PLEKHN1, PORCN, SEMA7A, SENP2, Stat1 dimer, STK36, SUFU, Tnf receptor, TNFRSF9, TNFRSF11A, TNFSF9, TRAF, TRAF1, TRAF5, TRAF2-TRAF5, TRAIP, TREM1, WNT4 | 27 | 28 | Cellular Assembly and Organization, Cellular Function and Maintenance, Skeletal and Muscular System Development and Function |
#5 | ANKRD29, APEX1, BAG5, CKB, CKMT1B, CNOT3, CNOT6, CNOT8, Creatine Kinase, DNAJA4, DNAJB6, DNAJC15, DNMBP, Fibrinogen, Hsp70, Hsp90, Hsp22/Hsp40/Hsp90, HSPA2, HSPA1A, ICAM1, IFT52, IP6K2, MIR1, Nos, Pka catalytic subunit, PLSCR1, SH3KBP1, SLC25A30, SPRY2, SRXN1, TIMP3, TNKS1BP1, TNPO2, TRIM2, XPNPEP3 | 26 | 27 | Cellular Assembly and Organization, Cellular Development, Cellular Growth and Proliferation |
Top 5 Networks in M1 | ||||
ID | Molecules in Network | Score | Focus Molecules | Top Functions |
#1 | ABCD1, AQP8, C13ORF15, CALML4, CCNE2, CDC7, DBF4, FXYD6, GALM, GIN1, GYG1, GYG2, GYS1, H1FX, HNMT, HYAL2, LPCAT3, ORC2L, ORC5L, ORC6L, OVOL1, PDLIM5, PHGDH, PSPH, RBM19, RBMS3, SBNO2, SEMA7A, SLC23A2, SLC25A14, SLC35A1, TBC1D1, TGFB1, TRIM7, UGDH | 41 | 35 | Carbohydrate Metabolism, DNA Replication, Recombination, and Repair, Embryonic Development |
#2 | ATAD3B, CAPZB, CHTF18, CPD, CPT2, FXC1, FXYD1, GAMT, GPC1, GTF3C2, GTF3C4, HMG CoA synthase, HMGCS1, HNRNPA0, IQGAP3, IREB2, LMNB2, LSM2, LSM6, LSM7, MINA, Mir125b (mouse), MYC, Ndpk, NME2, NME6, NME7, PDS5B, RAD21, RANBP6, REC8, RFX2, RNGTT, RRM2B, TOR2A | 34 | 32 | Cellular Assembly and Organization, Genetic Disorder, Metabolic Disease |
#3 | ACTN4, APEX2, ATRX, DNA-directed DNA polymerase, Erm, HOOK2, ICAM1, IGSF8, LAS1L, LIG3, LIG4, LRSAM1, MARCH3, MYOZ1, NEIL1, NOM1, PNKP, POLE2, POLG2, POLM, RNF2, RNF6, RNF10, RNF25, RNF166, RNF185, SLC9A1, TRIM37, TRP, TRPC4, UBE2D2, UBE2E3, UBE2 H (includes EG:7328), VIL1, ZNRF1 | 34 | 32 | DNA Replication, Recombination, and Repair, Gene Expression, Cell-mediated Immune Response |
#4 | ARL15, BRD1, BTBD2, C14ORF1, C1ORF103, CCDC106, CCDC90B, CD3EAP, CDKN3, DNA-directed RNA polymerase, EGLN1, EHMT2, FEZ1, FXR1, GTF3A, histone-lysine N-methyltransferase, KBTBD7, KIF11, KIF2C, KLK10, LMO2, MELK, POLR1A, POLR3 D, POLR3E, POLR3F, RIT1, SETDB1, S TAB2, THAP8 (includes EG:199745), TLE1, TMSB4X, UNC119, Vegf, ZNF24 (includes EG:7572) | 30 | 32 | Cell Cycle, Cellular Assembly and Organization, DNA Replication, Recombination, and Repair |
#5 | ABCC1, ABCD3, ACIN1, ATP5B, ATPase, CRISPLD2 (includes EG:83716), DTX1, DUSP1, E2F1, FABP1, FAM177A1, GRAP, IL34, Immunoglobulin, INHBA, INHBC, LIF, MAFF, MARK4, MIR124, MYH9, NAA15, NOTCH1, POMC, RDH10, RSF1, RYK, SKIV2L, SLC22A18AS, S TAB1, SYNGR2, Trypsin, WRN (includes EG:7486), WWP1, ZNF790 | 30 | 31 | Cellular Development, Nervous System Development and Function, Hematological System Development and Function |
Top 5 Networks in M2 | ||||
ID | Molecules in Network | Score | Focus Molecules | Top Functions |
#1 | AKR1C3, ARL15, C1ORF103, CETN3, DCP1A, DCTPP1, DDX6, DDX20, DNA-directed RNA polymerase, DUB, ETV3, FILIP1L, FXYD6, GANAB, GSTM3 (includes EG:2947), GTF3C4, GXYLT1, JMJD1C, NUP155, POLR1A, POLR1E, POLR3F, PRMT1, RHOF, RIF1, SDCCAG8, SNRPA1, TARS, TRAF6, UNC119, USP20, USP41, USP45, VHL, ZFP161 | 36 | 33 | Infection Mechanism, Infectious Disease, Cell Cycle |
#2 | ATN1, BANP, C8ORF4, CBFA2T2, CLK2, CLOCK, CRY1, DBP, EIF2B1, Fascin, H1FX, HIST1H2AE (includes EG:3012), Histone H1, HNRNPL, Importin beta, KHDRBS3, KIAA0913, LBR, LTBP4, LTC4 S, MAST2, OGG1, Pkc(s), RNF19A, SAFB, SDCBP2, SLC20A2, SRPK1, STK36, SUFU, TIMELESS, TM4SF1, TPM2, XPC, ZNF652 | 32 | 31 | Behavior, Nervous System Development and Function, Lipid Metabolism |
#3 | ATF7IP, ATPase, BACE1, CAPN3, CASP2, CASP7, CASP10, Caspase, CTRL, ENTPD2, hydrolase, ICAM1, IDE, ITM2C, KIAA1632, KYNU, LGMN, MAGED1, MEOX2, NAIP, NANP, NGFR, NUP160, PAPPA, peptidase, PLEKHF2 (includes EG:79666), RECQL5, RTN3, SENP5 (includes EG:205564), SPPL2B, SPTBN1, THTPA, UBAC2, UBR5, XAF1 | 32 | 31 | Protein Degradation, Protein Synthesis, Post-Translational Modification |
#4 | API5, ARRDC3, ASPH, Calbindin, CKB, CNNM4, COX11, COX15, COX10 (includes EG:1352), CPT1B, Creatine Kinase, Cytochrome c oxidase, ENO3, FICD, FOXP1, GPRASP2, HTR2B, HTT, JAKMIP1, KLF16, NDUFS1, NEFH, PHB (includes EG:5245), PPP1R16B, RCOR2, REST, RGS14, RNF34, SASH1, SCN4B, SNN, STRN, Thymidine Kinase, VAPA, WAC | 32 | 31 | Gene Expression, Neurological Disease, Cellular Compromise |
#5 | ALDH7A1, BPI, Cbp, Ciap, CLIP2, CST7, DBT, DUSP2, G0S2, GFPT2, KLF3, KRT19, lymphotoxin-alpha1-beta2, MICA, NFkB (complex), NKIRAS1, PELI3, POU2F2, RBCK1, REL/RELA/RELB, RNF216, S100P, S100Z, SH3RF1, SIAH2, SLC2A6, SNIP1, SUMO4, TNIP2, TRIM32, TRIM69, TXNRD1, WTAP, ZMYND11, ZNF71 | 30 | 30 | Carbohydrate Metabolism, Lipid Metabolism, Small Molecule Biochemistry |