Joint effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on risk of hyper-LDL cholesterolemia in middle-aged Japanese men

Table 1 Clinical characteristics of study subjects by Mt5178 C/A genotype

	Mt5178C	Mt5178A	P value
	N = 239	N = 155
Age (y)	54.3 ± 7.8	53.2 ± 7.8	0.171
Body Mass Index (kg/m²)	23.3 ± 2.8	23.5 ± 2.6	0.461
Systolic blood pressure (mmHg)	125.8 ± 15.9	125.7 ± 14.1	0.940
Diastolic blood pressure (mmHg)	74.0 ± 10.7	73.8 ± 9.1	0.829
Total cholesterol (mg/dl)	203.5 ± 34.3	201.9 ± 31.8	0.672
LDL cholesterol (mg/dl)	121.6 ± 34.8	117.9 ± 30.5	0.281
HDL cholesterol (mg/dl)	54.6 ± 13.6	56.3 ± 16.2	0.269
Triglyceride (mg/dl)	136.7 ± 91.1	139.5 ± 90.8	0.766
Fasting plasma glucose (mg/dl)	97.2 ± 9.4	97.6 ± 9.7	0.672
Uric acid (mg/dl)	5.98 ± 1.21	5.92 ± 1.21	0.673
Alcohol consumption (daily/occasional/non- or ex-) (%)	46.4/35.2/18.4	47.7/38.7/13.6	0.426
Coffee consumption (< 1 cup per day/1-3 cups per day/≥ 4 cups per day) (%)	44.8/46.0/9.2	36.8/51.6/11.6	0.274
Current smokers (%)	41.4	40.7	0.878
Antihypertensive medication use (%)	18.8	12.9	0.122
Hyper-LDL cholesterolemia (%)	26.4	25.8	0.903
Hypo-HDL cholesterolemia (%)	11.7	12.3	0.871
Hypertriglyceridemia (%)	29.7	29.7	0.995

LDL; low-density lipoprotein, HDL; high-density lipoprotein. Age, body mass index, systolic blood pressure, diastolic blood pressure, serum total cholesterol levels, serum LDL cholesterol levels, serum HDL cholesterol levels, serum triglyceride levels, fasting plasma glucose levels and serum uric acid levels are given as means ± S.D. All P values depict significance of differences between Mt5178C and Mt5178A. For alcohol consumption, coffee consumption, current smokers, antihypertensive medication use, hyper-LDL cholesterolemia, hypo-HDL cholesterolemia and hypertriglyceridemia, P values were calculated by chi-squared test.

ISSN: 1476-511X