Apoptosis in palmitate-exposed INS-1E cells (white bars), MIN6 cells (grey bars) and human islets (black bars) measured as DNA fragmentation. The cells and islets were cultured for 24 (A) and 48 (B) hours in the presence of 0.25, 0.5 and 1 mM palmitate. INS-1E cells cultured at 11 mM glucose, MIN6 cells at 25 mM glucose and human islets at 5.5 mM glucose alone were considered as controls. Results are means ± SEM of 3-4 independent experiments. *P < 0.05 compared to controls.