Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome

Table 3 Association of Ile405Val (rs5882) in the CETP gene with abdominal obesity and low HDL-cholesterol levels

Outcome^a	Ile/Ile	Ile/Val	Val/Val	PR/allele (95%CI)^b	P-trend
Prevalence of low HDL ^c
Overall (n = 669, total n = 2959)	26.0%	20.6%	14.4%	0.76 (0.69;0.86)	< .0001
Adjusted for abdominal obesity (n = 669, total n = 2959)	24.7%	21.3%	16.0%	0.83 (0.74;0.93)	0.002
Among subjects without abdominal obesity (n = 252, total n = 1684)	18.4%	13.0%	7.8%	0.68 (0.56;0.82)	< 0.001
Prevalence of abdominal obesity ^d
Overall (n = 958, total n = 2931)	34.7%	31.9%	26.4%	0.90 (0.83;0.97)	0.0072
Adjusted for low HDL (n = 958, total n = 2931)	33.1%	30.4%	27.0%	0.92 (0.83;1)	0.05
Among subjects with high HDL levels (n = 470, total n = 1902)	27.9%	22.8%	18.7%	0.82 (0.73;0.93)	0.0014
Prevalence of both low HDL and abdominal obesity ^e
Overall (n = 298, total n = 1730)	19.5%	16.3%	11.2%	0.81 (0.69;0.94)	0.0076

PR = Prevalence Ratio
^a All analyses are adjusted for age and sex
^b Prevalence ratios are expressed per minor VAL allele assuming an additive genetic model
^c Subjects with low HDL-cholesterol in round 2, but not in round 3 or vice versa, were excluded
^d Subjects with abdominal obesity in round 2, but not round 3 or vice versa, were excluded
^e Only subjects with either both abdominal obesity and low HDL-cholesterol levels in round 2 and 3 or with both no abdominal obesity and high HDL-cholesterol levels were included. Subjects without abdominal obesity and with high HDL-cholesterol levels in round 2 and 3 were used as the reference category

ISSN: 1476-511X