Skip to main content

Table 3 Association of Ile405Val (rs5882) in the CETP gene with abdominal obesity and low HDL-cholesterol levels

From: Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome

Outcomea Ile/Ile Ile/Val Val/Val PR/allele (95%CI)b P-trend
Prevalence of low HDL c      
Overall
(n = 669, total n = 2959)
26.0% 20.6% 14.4% 0.76 (0.69;0.86) < .0001
Adjusted for abdominal obesity
(n = 669, total n = 2959)
24.7% 21.3% 16.0% 0.83 (0.74;0.93) 0.002
Among subjects without abdominal obesity
(n = 252, total n = 1684)
18.4% 13.0% 7.8% 0.68 (0.56;0.82) < 0.001
Prevalence of abdominal obesity d      
Overall
(n = 958, total n = 2931)
34.7% 31.9% 26.4% 0.90 (0.83;0.97) 0.0072
Adjusted for low HDL
(n = 958, total n = 2931)
33.1% 30.4% 27.0% 0.92 (0.83;1) 0.05
Among subjects with high HDL levels
(n = 470, total n = 1902)
27.9% 22.8% 18.7% 0.82 (0.73;0.93) 0.0014
Prevalence of both low HDL and abdominal obesity e      
Overall
(n = 298, total n = 1730)
19.5% 16.3% 11.2% 0.81 (0.69;0.94) 0.0076
  1. PR = Prevalence Ratio
  2. a All analyses are adjusted for age and sex
  3. b Prevalence ratios are expressed per minor VAL allele assuming an additive genetic model
  4. c Subjects with low HDL-cholesterol in round 2, but not in round 3 or vice versa, were excluded
  5. d Subjects with abdominal obesity in round 2, but not round 3 or vice versa, were excluded
  6. e Only subjects with either both abdominal obesity and low HDL-cholesterol levels in round 2 and 3 or with both no abdominal obesity and high HDL-cholesterol levels were included. Subjects without abdominal obesity and with high HDL-cholesterol levels in round 2 and 3 were used as the reference category