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Table 4 Association of Cys112Arg (rs429358) in the APOE gene with abdominal obesity and low HDL-cholesterol levels

From: Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome

Outcomea

Cys/Cys

Cys/Arg

Arg/Arg

PR/allele (95%CI)b

P-trend

Prevalence of low HDL c

     

Overall

(n = 669, total n = 2959)

21.2%

25.5%

32.3%

1.21 (1.07;1.37)

0.0013

Adjusted for abdominal obesity

(n = 669, total n = 2959)

21.0%

25.5%

30.2%

1.20 (1.06;1.36)

0.005

Among subjects without abdominal obesity

(n = 252, total n = 1684)

13.5%

18.0%

26.0%

1.35 (1.11; 1.65)

0.0031

Prevalence of abdominal obesity d

     

Overall

(n = 958, total n = 2931)

31.2%

35.8%

39.6%

1.12 (1.03;1.23)

0.0074

Adjusted for low HDL

(n = 958, total n = 2931)

30.1%

33.1%

38.9%

1.12 (1.0l;1.25)

0.04

Among subjects with high HDL levels

(n = 470, total n = 1902)

23.5%

27.3%

34.5%

1.16 (1.01;1.33)

0.03

Prevalence of both low HDL and abdominal obesity e

     

Overall

(n = 298, total n = 1730)

15.7%

20.7%

27.8%

1.29 (1.08;1.54)

0.0045

  1. PR = Prevalence Ratio
  2. aAll analyses are adjusted for age and sex
  3. b Prevalence ratios are expressed per minor ARG allele assuming an additive genetic model
  4. c Subjects with low HDL-cholesterol in round 2, but not in round 3 or vice versa, were excluded
  5. d Subjects with abdominal obesity in round 2, but not round 3 or vice versa, were excluded
  6. e Only subjects with either both abdominal obesity and low HDL-cholesterol levels in round 2 and 3 or with both no abdominal obesity and high HDL-cholesterol levels were included. Subjects without abdominal obesity and with high HDL-cholesterol levels in round 2 and 3 were used as the reference category