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Table 4 Association of Cys112Arg (rs429358) in the APOE gene with abdominal obesity and low HDL-cholesterol levels

From: Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome

Outcomea Cys/Cys Cys/Arg Arg/Arg PR/allele (95%CI)b P-trend
Prevalence of low HDL c      
Overall
(n = 669, total n = 2959)
21.2% 25.5% 32.3% 1.21 (1.07;1.37) 0.0013
Adjusted for abdominal obesity
(n = 669, total n = 2959)
21.0% 25.5% 30.2% 1.20 (1.06;1.36) 0.005
Among subjects without abdominal obesity
(n = 252, total n = 1684)
13.5% 18.0% 26.0% 1.35 (1.11; 1.65) 0.0031
Prevalence of abdominal obesity d      
Overall
(n = 958, total n = 2931)
31.2% 35.8% 39.6% 1.12 (1.03;1.23) 0.0074
Adjusted for low HDL
(n = 958, total n = 2931)
30.1% 33.1% 38.9% 1.12 (1.0l;1.25) 0.04
Among subjects with high HDL levels
(n = 470, total n = 1902)
23.5% 27.3% 34.5% 1.16 (1.01;1.33) 0.03
Prevalence of both low HDL and abdominal obesity e      
Overall
(n = 298, total n = 1730)
15.7% 20.7% 27.8% 1.29 (1.08;1.54) 0.0045
  1. PR = Prevalence Ratio
  2. aAll analyses are adjusted for age and sex
  3. b Prevalence ratios are expressed per minor ARG allele assuming an additive genetic model
  4. c Subjects with low HDL-cholesterol in round 2, but not in round 3 or vice versa, were excluded
  5. d Subjects with abdominal obesity in round 2, but not round 3 or vice versa, were excluded
  6. e Only subjects with either both abdominal obesity and low HDL-cholesterol levels in round 2 and 3 or with both no abdominal obesity and high HDL-cholesterol levels were included. Subjects without abdominal obesity and with high HDL-cholesterol levels in round 2 and 3 were used as the reference category