Table 2 The lipid profiles among young adolescents with different IL-6R genotypes
| Â | Â | Wild-type | Heterozygotes | Minor-type | Â |
|---|---|---|---|---|---|
|  |  | mean ± s.d. | mean ± s.d. | mean ± s.d. | pa |
Boys (n = 418) | Â | Â | Â | Â | Â |
rs4845617 G/A | Â | GG (n = 123) | GA (n = 199) | AA (n = 96) | Â |
|  | CHOL (mg/dl) | 158.7 ± 25.9 | 161.4 ± 28.4 | 156.7 ± 25.4 | 0.71 |
|  | TG (mg/dl) | 70.1 ± 29.9 | 70.2 ± 34.4 | 63.5 ± 31.3 | 0.07 |
|  | HDL-C (mg/dl) | 49.0 ± 11.0 | 50.7 ± 11.7 | 48.8 ± 12.0 | 0.95 |
|  | LDL-C (mg/dl) | 80.5 ± 18.2 | 81.7 ± 19.6 | 80.6 ± 19.7 | 0.84 |
|  | CHOL/HDL-C | 3.38 ± 0.84 | 3.32 ± 0.85 | 3.39 ± 1.01 | 0.85 |
|  | LDL-C/HDL-C | 1.73 ± 0.57 | 1.70 ± 0.95 | 1.77 ± 0.69 | 0.89 |
|  | TG/HDL-C | 1.57 ± 0.94 | 1.52 ± 1.02 | 1.47 ± 1.08 | 0.18 |
rs4845623 A/G | Â | AA (n = 290) | AG (n = 116) | GG (n = 12) | Â |
|  | CHOL (mg/dl) | 160.0 ± 27.2 | 158.8 ± 26.8 | 155.3 ± 26.0 | 0.51 |
|  | TG (mg/dl) | 68.0 ± 32.0 | 71.1 ± 33.8 | 59.3 ± 30.1 | 0.87 |
|  | HDL-C (mg/dl) | 49.7 ± 11.6 | 49.3 ± 11.4 | 56.7 ± 11.3 | 0.44 |
|  | LDL-C (mg/dl) | 81.8 ± 19.2 | 80.4 ± 19.4 | 72.0 ± 16.5 | 0.12 |
|  | CHOL/HDL-C | 3.36 ± 0.86 | 3.38 ± 0.96 | 2.80 ± 0.48 | 0.24 |
|  | LDL-C/HDL-C | 1.74 ± 0.59 | 1.73 ± 0.65 | 1.31 ± 0.36 | 0.09 |
|  | TG/HDL-C | 1.51 ± 0.98 | 1.61 ± 1.11 | 1.05 ± 0.46 | 0.84 |
rs8192284 A/C | Â | AA (n = 161) | AC (n = 202) | CC (n = 55) | Â |
|  | CHOL (mg/dl) | 158.8 ± 28.6 | 159.6 ± 26.0 | 161.3 ± 25.9 | 0.64 |
|  | TG (mg/dl) | 69.9 ± 33.5 | 70.3 ± 33.8 | 58.7 ± 21.2 | 0.07 |
|  | HDL-C (mg/dl) | 48.9 ± 10.6 | 50.2 ± 12.5 | 50.6 ± 10.7 | 0.22 |
|  | LDL-C (mg/dl) | 80.4 ± 20.2 | 80.9 ± 18.7 | 83.9 ± 18.2 | 0.37 |
|  | CHOL/HDL-C | 3.38 ± 0.89 | 3.35 ± 0.93 | 3.28 ± 0.71 | 0.46 |
|  | LDL-C/HDL-C | 1.73 ± 0.60 | 1.73 ± 0.64 | 1.72 ± 0.51 | 0.93 |
|  | TG/HDL-C | 1.57 ± 1.05 | 1.56 ± 1.05 | 1.24 ± 0.62 | 0.06 |
rs2229238 C/T | Â | CC (n = 169) | CT (n = 192) | TT (n = 57) | Â |
|  | CHOL (mg/dl) | 158.3 ± 28.9 | 160.0 ± 25.7 | 161.2 ± 25.6 | 0.51 |
|  | TG (mg/dl) | 70.2 ± 33.3 | 70.0 ± 34.1 | 59.5 ± 21.5 | 0.07 |
|  | HDL-C (mg/dl) | 49.3 ± 10.9 | 50.1 ± 12.3 | 50.1 ± 11.0 | 0.49 |
|  | LDL-C (mg/dl) | 79.7 ± 20.7 | 81.5 ± 18.1 | 84.0 ± 18.4 | 0.17 |
|  | CHOL/HDL-C | 3.35 ± 0.90 | 3.36 ± 0.91 | 3.33 ± 0.78 | 0.96 |
|  | LDL-C/HDL-C | 1.71 ± 0.61 | 1.74 ± 0.62 | 1.75 ± 0.57 | 0.47 |
|  | TG/HDL-C | 1.57 ± 1.04 | 1.56 ± 1.06 | 1.27 ± 0.63 | 0.09 |
Girls (n = 441) | Â | Â | Â | Â | Â |
rs4845617 G/A | Â | GG (n = 130) | GA (n = 211) | AA (n = 100) | Â |
|  | CHOL (mg/dl) | 167.1 ± 26.0 | 168.7 ± 28.5 | 169.8 ± 28.2 | 0.47 |
|  | TG (mg/dl) | 66.8 ± 27.0 | 69.6 ± 31.0 | 74.0 ± 32.1 | 0.11 |
|  | HDL-C (mg/dl) | 51.7 ± 11.2 | 52.5 ± 12.2 | 49.9 ± 10.3 | 0.31 |
|  | LDL-C (mg/dl) | 85.3 ± 18.3 | 86.7 ± 21.0 | 87.4 ± 20.6 | 0.44 |
|  | CHOL/HDL-C | 3.33 ± 0.70 | 3.36 ± 0.89 | 3.52 ± 0.80 | 0.16 |
|  | LDL-C/HDL-C | 1.72 ± 0.50 | 1.74 ± 0.60 | 1.82 ± 0.55 | 0.26 |
|  | TG/HDL-C | 1.37 ± 0.72 | 1.47 ± 1.01 | 1.59 ± 0.96 | 0.09 |
rs4845623 A/G | Â | AA (n = 314) | AG (n = 115) | GG (n = 12) | Â |
|  | CHOL (mg/dl) | 167.3 ± 27.9 | 170.5 ± 27.3 | 178.4 ± 23.7 | 0.17 |
|  | TG (mg/dl) | 71.1 ± 31.7 | 67.5 ± 26.8 | 58.4 ± 15.3 | 0.24 |
|  | HDL-C (mg/dl) | 50.7 ± 11.0 | 54.2 ± 12.8 | 51.7 ± 10.0 | 0.04 |
|  | LDL-C (mg/dl) | 86.0 ± 20.7 | 86.8 ± 18.9 | 93.1 ± 14.2 | 0.44 |
|  | CHOL/HDL-C | 3.43 ± 0.85 | 3.27 ± 0.73 | 3.54 ± 0.63 | 0.37 |
|  | LDL-C/HDL-C | 1.78 ± 0.58 | 1.68 ± 0.51 | 1.87 ± 0.46 | 0.52 |
|  | TG/HDL-C | 1.53 ± 1.01 | 1.34 ± 0.66 | 1.17 ± 0.40 | 0.07 |
rs8192284 A/C | Â | AA (n = 148) | AC (n = 216) | CC (n = 77) | Â |
|  | CHOL (mg/dl) | 166.8 ± 26.9 | 168.6 ± 27.6 | 171.4 ± 29.3 | 0.21 |
|  | TG (mg/dl) | 66.6 ± 24.8 | 70.5 ± 30.3 | 73.9 ± 38.0 | 0.24 |
|  | HDL-C (mg/dl) | 52.8 ± 11.7 | 51.6 ± 11.8 | 49.8 ± 10.2 | 0.09 |
|  | LDL-C (mg/dl) | 84.7 ± 18.7 | 86.7 ± 20.9 | 89.2 ± 20.3 | 0.11 |
|  | CHOL/HDL-C | 3.26 ± 0.66 | 3.42 ± 0.90 | 3.56 ± 0.84 | 0.01 |
|  | LDL-C/HDL-C | 1.67 ± 0.48 | 1.77 ± 0.61 | 1.86 ± 0.54 | 0.02 |
|  | TG/HDL-C | 1.34 ± 0.61 | 1.51 ± 0.99 | 1.62 ± 1.18 | 0.10 |
rs2229238 C/T | Â | CC (n = 156) | CT (n = 202) | TT (n = 83) | Â |
|  | CHOL (mg/dl) | 166.7 ± 27.2 | 168.6 ± 27.0 | 171.5 ± 30.2 | 0.17 |
|  | TG (mg/dl) | 66.3 ± 24.6 | 70.9 ± 30.9 | 73.6 ± 36.9 | 0.16 |
|  | HDL-C (mg/dl) | 52.9 ± 11.9 | 51.5 ± 11.7 | 49.8 ± 10.4 | 0.07 |
|  | LDL-C (mg/dl) | 84.5 ± 18.9 | 86.7 ± 20.8 | 89.2 ± 20.5 | 0.08 |
|  | CHOL/HDL-C | 3.25 ± 0.66 | 3.43 ± 0.90 | 3.56 ± 0.84 | 0.008 |
|  | LDL-C/HDL-C | 1.66 ± 0.48 | 1.78 ± 0.61 | 1.86 ± 0.54 | 0.01 |
|  | TG/HDL-C | 1.33 ± 0.61 | 1.52 ± 1.01 | 1.61 ± 1.15 | 0.06 |