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Table 2 The lipid profiles among young adolescents with different IL-6R genotypes

From: Association between interleukin-6 receptor gene variations and atherosclerotic lipid profiles among young adolescents in Taiwan

   Wild-type Heterozygotes Minor-type  
   mean ± s.d. mean ± s.d. mean ± s.d. pa
Boys (n = 418)      
rs4845617 G/A   GG (n = 123) GA (n = 199) AA (n = 96)  
  CHOL (mg/dl) 158.7 ± 25.9 161.4 ± 28.4 156.7 ± 25.4 0.71
  TG (mg/dl) 70.1 ± 29.9 70.2 ± 34.4 63.5 ± 31.3 0.07
  HDL-C (mg/dl) 49.0 ± 11.0 50.7 ± 11.7 48.8 ± 12.0 0.95
  LDL-C (mg/dl) 80.5 ± 18.2 81.7 ± 19.6 80.6 ± 19.7 0.84
  CHOL/HDL-C 3.38 ± 0.84 3.32 ± 0.85 3.39 ± 1.01 0.85
  LDL-C/HDL-C 1.73 ± 0.57 1.70 ± 0.95 1.77 ± 0.69 0.89
  TG/HDL-C 1.57 ± 0.94 1.52 ± 1.02 1.47 ± 1.08 0.18
rs4845623 A/G   AA (n = 290) AG (n = 116) GG (n = 12)  
  CHOL (mg/dl) 160.0 ± 27.2 158.8 ± 26.8 155.3 ± 26.0 0.51
  TG (mg/dl) 68.0 ± 32.0 71.1 ± 33.8 59.3 ± 30.1 0.87
  HDL-C (mg/dl) 49.7 ± 11.6 49.3 ± 11.4 56.7 ± 11.3 0.44
  LDL-C (mg/dl) 81.8 ± 19.2 80.4 ± 19.4 72.0 ± 16.5 0.12
  CHOL/HDL-C 3.36 ± 0.86 3.38 ± 0.96 2.80 ± 0.48 0.24
  LDL-C/HDL-C 1.74 ± 0.59 1.73 ± 0.65 1.31 ± 0.36 0.09
  TG/HDL-C 1.51 ± 0.98 1.61 ± 1.11 1.05 ± 0.46 0.84
rs8192284 A/C   AA (n = 161) AC (n = 202) CC (n = 55)  
  CHOL (mg/dl) 158.8 ± 28.6 159.6 ± 26.0 161.3 ± 25.9 0.64
  TG (mg/dl) 69.9 ± 33.5 70.3 ± 33.8 58.7 ± 21.2 0.07
  HDL-C (mg/dl) 48.9 ± 10.6 50.2 ± 12.5 50.6 ± 10.7 0.22
  LDL-C (mg/dl) 80.4 ± 20.2 80.9 ± 18.7 83.9 ± 18.2 0.37
  CHOL/HDL-C 3.38 ± 0.89 3.35 ± 0.93 3.28 ± 0.71 0.46
  LDL-C/HDL-C 1.73 ± 0.60 1.73 ± 0.64 1.72 ± 0.51 0.93
  TG/HDL-C 1.57 ± 1.05 1.56 ± 1.05 1.24 ± 0.62 0.06
rs2229238 C/T   CC (n = 169) CT (n = 192) TT (n = 57)  
  CHOL (mg/dl) 158.3 ± 28.9 160.0 ± 25.7 161.2 ± 25.6 0.51
  TG (mg/dl) 70.2 ± 33.3 70.0 ± 34.1 59.5 ± 21.5 0.07
  HDL-C (mg/dl) 49.3 ± 10.9 50.1 ± 12.3 50.1 ± 11.0 0.49
  LDL-C (mg/dl) 79.7 ± 20.7 81.5 ± 18.1 84.0 ± 18.4 0.17
  CHOL/HDL-C 3.35 ± 0.90 3.36 ± 0.91 3.33 ± 0.78 0.96
  LDL-C/HDL-C 1.71 ± 0.61 1.74 ± 0.62 1.75 ± 0.57 0.47
  TG/HDL-C 1.57 ± 1.04 1.56 ± 1.06 1.27 ± 0.63 0.09
Girls (n = 441)      
rs4845617 G/A   GG (n = 130) GA (n = 211) AA (n = 100)  
  CHOL (mg/dl) 167.1 ± 26.0 168.7 ± 28.5 169.8 ± 28.2 0.47
  TG (mg/dl) 66.8 ± 27.0 69.6 ± 31.0 74.0 ± 32.1 0.11
  HDL-C (mg/dl) 51.7 ± 11.2 52.5 ± 12.2 49.9 ± 10.3 0.31
  LDL-C (mg/dl) 85.3 ± 18.3 86.7 ± 21.0 87.4 ± 20.6 0.44
  CHOL/HDL-C 3.33 ± 0.70 3.36 ± 0.89 3.52 ± 0.80 0.16
  LDL-C/HDL-C 1.72 ± 0.50 1.74 ± 0.60 1.82 ± 0.55 0.26
  TG/HDL-C 1.37 ± 0.72 1.47 ± 1.01 1.59 ± 0.96 0.09
rs4845623 A/G   AA (n = 314) AG (n = 115) GG (n = 12)  
  CHOL (mg/dl) 167.3 ± 27.9 170.5 ± 27.3 178.4 ± 23.7 0.17
  TG (mg/dl) 71.1 ± 31.7 67.5 ± 26.8 58.4 ± 15.3 0.24
  HDL-C (mg/dl) 50.7 ± 11.0 54.2 ± 12.8 51.7 ± 10.0 0.04
  LDL-C (mg/dl) 86.0 ± 20.7 86.8 ± 18.9 93.1 ± 14.2 0.44
  CHOL/HDL-C 3.43 ± 0.85 3.27 ± 0.73 3.54 ± 0.63 0.37
  LDL-C/HDL-C 1.78 ± 0.58 1.68 ± 0.51 1.87 ± 0.46 0.52
  TG/HDL-C 1.53 ± 1.01 1.34 ± 0.66 1.17 ± 0.40 0.07
rs8192284 A/C   AA (n = 148) AC (n = 216) CC (n = 77)  
  CHOL (mg/dl) 166.8 ± 26.9 168.6 ± 27.6 171.4 ± 29.3 0.21
  TG (mg/dl) 66.6 ± 24.8 70.5 ± 30.3 73.9 ± 38.0 0.24
  HDL-C (mg/dl) 52.8 ± 11.7 51.6 ± 11.8 49.8 ± 10.2 0.09
  LDL-C (mg/dl) 84.7 ± 18.7 86.7 ± 20.9 89.2 ± 20.3 0.11
  CHOL/HDL-C 3.26 ± 0.66 3.42 ± 0.90 3.56 ± 0.84 0.01
  LDL-C/HDL-C 1.67 ± 0.48 1.77 ± 0.61 1.86 ± 0.54 0.02
  TG/HDL-C 1.34 ± 0.61 1.51 ± 0.99 1.62 ± 1.18 0.10
rs2229238 C/T   CC (n = 156) CT (n = 202) TT (n = 83)  
  CHOL (mg/dl) 166.7 ± 27.2 168.6 ± 27.0 171.5 ± 30.2 0.17
  TG (mg/dl) 66.3 ± 24.6 70.9 ± 30.9 73.6 ± 36.9 0.16
  HDL-C (mg/dl) 52.9 ± 11.9 51.5 ± 11.7 49.8 ± 10.4 0.07
  LDL-C (mg/dl) 84.5 ± 18.9 86.7 ± 20.8 89.2 ± 20.5 0.08
  CHOL/HDL-C 3.25 ± 0.66 3.43 ± 0.90 3.56 ± 0.84 0.008
  LDL-C/HDL-C 1.66 ± 0.48 1.78 ± 0.61 1.86 ± 0.54 0.01
  TG/HDL-C 1.33 ± 0.61 1.52 ± 1.01 1.61 ± 1.15 0.06
  1. Abbreviation: CHOL, Cholesterol; TG, Triglycerides; HDL-C, High density lipoprotein-cholesterol; LDL-C, Low density lipoprotein-cholesterol.
  2. a Using GLM test after adjusting for age, cigarette smoking, alcohol drinking, and puberty status.