Lipids in Health and Disease

Table 3 Logistic regression analyses of different IL-6R genotypes on lipid status among young adolescents ^a

From: Association between interleukin-6 receptor gene variations and atherosclerotic lipid profiles among young adolescents in Taiwan

	Model type	rs4845617 G/A		rs4845623 A/G		rs8192284 A/C		rs2229238 C/T
		OR	95%CI	OR	95%CI	OR	95%CI	OR	95%CI
Boys
High CHOL	additive	0.91	0.55-1.50	1.10	0.58-2.06	0.90	0.53-1.52	0.81	0.48-1.36
	dominant	0.74	0.29-1.86	0.77	0.09-6.39	1.36	0.53-3.50	1.32	0.51-3.38
	recessive	1.01	0.46-2.19	1.18	0.56-2.47	0.70	0.35-1.42	0.58	0.29-1.17
High TG	additive	0.92	0.61-1.40	1.45	0.85-2.46	0.85	0.54-1.34	0.81	0.51-1.27
	dominant	0.95	0.46-1.97	1.56	0.32-7.50	0.39	0.12-1.32	0.38	0.11-1.26
	recessive	0.86	0.45-1.63	1.55	0.83-2.91	1.04	0.56-1.94	0.95	0.52-1.75
High HDL-C	additive	1.02	0.70-1.49	0.98	0.58-1.64	0.78	0.51-1.18	0.84	0.56-1.27
	dominant	1.35	0.72-2.52	0.51	0.06-4.04	0.68	0.28-1.68	0.79	0.34-1.85
	recessive	0.81	0.45-1.45	1.04	0.58-1.89	0.74	0.43-1.28	0.81	0.46-1.40
High LDL-C	additive	0.78	0.49-1.26	0.81	0.42-1.57	0.83	0.50-1.39	0.81	0.49-1.34
	dominant	0.94	0.41-2.15	-	-	1.22	0.48-3.09	1.18	0.46-2.97
	recessive	0.60	0.30-1.21	0.90	0.43-1.90	0.65	0.33-1.27	0.62	0.32-1.22
High CHOL/HDL-C	additive	1.24	0.79-1.93	0.74	0.38-1.43	0.70	0.43-1.16	0.78	0.48-1.27
	dominant	1.39	0.67-2.89	-	-	0.30	0.07-1.26	0.45	0.13-1.51
	recessive	1.28	0.61-2.66	0.81	0.39-1.67	0.79	0.41-1.51	0.86	0.45-1.64
Girls
High CHOL	additive	1.23	0.79-1.93	0.96	0.51-1.79	1.13	0.71-1.80	1.20	0.77-1.88
	dominant	1.15	0.55-2.43	1.78	0.36-8.79	1.51	0.70-3.27	1.60	0.76-3.38
	recessive	1.55	0.71-3.36	0.85	0.41-1.78	0.97	0.49-1.92	1.07	0.54-2.12
High TG	additive	1.59	1.06-2.37	0.57	0.30-1.09	1.58	1.05-2.37	1.55	1.04-2.29
	dominant	1.77	0.95-3.28	-	-	1.53	0.77-3.02	1.54	0.79-2.99
	recessive	2.00	0.97-4.11	0.59	0.29-1.19	2.21	1.10-4.44	2.14	1.09-4.20
High HDL-C	additive	1.24	0.83-1.86	0.76	0.41-1.41	1.57	1.03-2.39	1.68	1.12-2.52
	dominant	1.24	0.64-2.41	0.73	0.09-5.94	1.67	0.84-3.32	1.90	0.98-3.67
	recessive	1.46	0.74-2.92	0.74	0.37-1.46	1.98	0.99-4.00	2.16	1.07-4.35
High LDL-C	additive	1.08	0.70-1.65	1.01	0.56-1.82	1.10	0.71-1.71	1.22	0.80-1.86
	dominant	0.87	0.41-1.84	0.75	0.09-6.08	0.77	0.33-1.82	0.99	0.45-2.16
	recessive	1.38	0.68-2.83	1.05	0.53-2.05	1.48	0.74-2.96	1.63	0.81-3.25
High CHOL/HDL-C	additive	1.27	0.83-1.94	0.70	0.37-1.36	1.68	1.08-2.61	1.82	1.18-2.79
	dominant	1.38	0.69-2.75	1.75	0.36-8.56	1.35	0.64-2.86	1.61	0.79-3.27
	recessive	1.38	0.68-2.82	0.57	0.27-1.22	3.17	1.37-7.30	3.47	1.51-8.00

Abbreviation: CHOL, Cholesterol; TG, Triglycerides; HDL-C, High density lipoprotein-cholesterol; LDL-C, Low density lipoprotein-cholesterol.
additive model: major-homozygotes v.s. heterozygotes v.s. minor-homozygotes, reference group: major-homozygotes.
dominant model: major-homozygotes/heterozygotes v.s. minor-homozygotes, reference group: major-homozygotes/heterozygotes.
recessive model: major-homozygotes v.s. heterozygotes/minor-homozygotes; reference group: major-homozygotes.
^a All abnormal variables defined as age- and gender-specific 90^th percentile cut-off point of study variables and OR was adjusted for age, cigarette smoking, alcohol drinking, and puberty status.

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