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Table 4 Haplotype frequencies of IL-6R gene and associated with lipid status among young adolescents a

From: Association between interleukin-6 receptor gene variations and atherosclerotic lipid profiles among young adolescents in Taiwan

 

Haplotypeb

Abnormal

Normal

OR

95%CI

p

Global p

  

HF

HF

    

Boys

       

High TG

H1

0.35

0.33

1.00

-

-

0.75

 

H2

0.08

0.10

0.49

0.08-2.84

0.43

 
 

H3

0.13

0.10

1.27

0.27-5.91

0.76

 
 

H4

0.13

0.14

0.68

0.15-2.98

0.61

 
 

H5

0.24

0.27

0.61

0.20-1.90

0.39

 

Low HDL-C

H1

0.39

0.32

1.00

-

-

0.29

 

H2

0.07

0.10

0.31

0.06-1.60

0.16

 
 

H3

0.07

0.11

0.23

0.04-1.18

0.08

 
 

H4

0.13

0.14

0.47

0.13-1.78

0.27

 
 

H5

0.24

0.27

0.51

0.18-1.38

0.18

 

Abnormal lipidc

H1

0.36

0.32

1.00

-

-

0.84

 

H2

0.09

0.10

0.64

0.17-2.41

0.51

 
 

H3

0.09

0.11

0.55

0.14-2.10

0.38

 
 

H4

0.14

0.14

0.68

0.21-2.18

0.51

 
 

H5

0.24

0.27

0.64

0.26-1.57

0.33

 

High CHOL/HDL-C

H1

0.37

0.33

1.00

-

-

0.19

 

H2

0.06

0.10

0.27

0.03-2.29

0.23

 
 

H3

0.05

0.11

0.16

0.02-1.45

0.10

 
 

H4

0.19

0.14

1.26

0.32-5.02

0.74

 
 

H5

0.25

0.27

0.63

0.19-2.05

0.44

 

Girls

       

High TG

H1

0.21

0.30

1.00

-

-

0.04

 

H2

0.16

0.13

2.75

0.62-12.26

0.19

 
 

H3

0.06

0.12

0.47

0.06-3.64

0.47

 
 

H4

0.17

0.13

3.22

0.68-15.36

0.14

 
 

H5

0.36

0.28

3.08

1.07-8.87

0.04

 

Low HDL-C

H1

0.22

0.30

1.00

-

-

0.13

 

H2

0.17

0.12

3.56

0.81-15.53

0.09

 
 

H3

0.09

0.11

1.35

0.23-8.04

0.74

 
 

H4

0.12

0.14

1.45

0.24-8.81

0.69

 
 

H5

0.37

0.28

3.30

1.11-9.85

0.03

 

Abnormal lipid

H1

0.22

0.31

1.00

-

-

0.03

 

H2

0.16

0.12

2.93

0.85-10.03

0.09

 
 

H3

0.08

0.12

0.91

0.20-4.07

0.90

 
 

H4

0.15

0.13

2.57

0.67-9.85

0.17

 
 

H5

0.36

0.27

3.22

1.34-7.76

0.009

 

High CHOL/HDL-C

H1

0.21

0.30

1.00

-

-

0.08

 

H2

0.17

0.12

4.66

0.97-22.38

0.05

 
 

H3

0.10

0.11

2.05

0.32-13.28

0.45

 
 

H4

0.11

0.14

1.97

0.29-13.46

0.49

 
 

H5

0.38

0.28

4.40

1.35-14.32

0.01

 
  1. Abbreviation: CHOL, Cholesterol; TG, Triglycerides; HDL-C, High density lipoprotein-cholesterol; LDL-C, Low density lipoprotein-cholesterol; HF, Haplotype frequency
  2. a All abnormal variables defined as age- and gender-specific 90th percentile cut-off point of study variables
  3. b Five common haplotype frequencies of IL-6R rs4845617 G/A, rs4845623 A/G, and rs2229238 C/T (H1: GAC, H2: GAT, H3: GGC, H5: AAC, H6: AAT) at least 5% and H1 as reference group.
  4. c Abnormal lipid includes high TG or low HDL-C
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Lipids in Health and Disease

ISSN: 1476-511X