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Table 4 Haplotype frequencies of IL-6R gene and associated with lipid status among young adolescents a

From: Association between interleukin-6 receptor gene variations and atherosclerotic lipid profiles among young adolescents in Taiwan

  Haplotypeb Abnormal Normal OR 95%CI p Global p
   HF HF     
Boys        
High TG H1 0.35 0.33 1.00 - - 0.75
  H2 0.08 0.10 0.49 0.08-2.84 0.43  
  H3 0.13 0.10 1.27 0.27-5.91 0.76  
  H4 0.13 0.14 0.68 0.15-2.98 0.61  
  H5 0.24 0.27 0.61 0.20-1.90 0.39  
Low HDL-C H1 0.39 0.32 1.00 - - 0.29
  H2 0.07 0.10 0.31 0.06-1.60 0.16  
  H3 0.07 0.11 0.23 0.04-1.18 0.08  
  H4 0.13 0.14 0.47 0.13-1.78 0.27  
  H5 0.24 0.27 0.51 0.18-1.38 0.18  
Abnormal lipidc H1 0.36 0.32 1.00 - - 0.84
  H2 0.09 0.10 0.64 0.17-2.41 0.51  
  H3 0.09 0.11 0.55 0.14-2.10 0.38  
  H4 0.14 0.14 0.68 0.21-2.18 0.51  
  H5 0.24 0.27 0.64 0.26-1.57 0.33  
High CHOL/HDL-C H1 0.37 0.33 1.00 - - 0.19
  H2 0.06 0.10 0.27 0.03-2.29 0.23  
  H3 0.05 0.11 0.16 0.02-1.45 0.10  
  H4 0.19 0.14 1.26 0.32-5.02 0.74  
  H5 0.25 0.27 0.63 0.19-2.05 0.44  
Girls        
High TG H1 0.21 0.30 1.00 - - 0.04
  H2 0.16 0.13 2.75 0.62-12.26 0.19  
  H3 0.06 0.12 0.47 0.06-3.64 0.47  
  H4 0.17 0.13 3.22 0.68-15.36 0.14  
  H5 0.36 0.28 3.08 1.07-8.87 0.04  
Low HDL-C H1 0.22 0.30 1.00 - - 0.13
  H2 0.17 0.12 3.56 0.81-15.53 0.09  
  H3 0.09 0.11 1.35 0.23-8.04 0.74  
  H4 0.12 0.14 1.45 0.24-8.81 0.69  
  H5 0.37 0.28 3.30 1.11-9.85 0.03  
Abnormal lipid H1 0.22 0.31 1.00 - - 0.03
  H2 0.16 0.12 2.93 0.85-10.03 0.09  
  H3 0.08 0.12 0.91 0.20-4.07 0.90  
  H4 0.15 0.13 2.57 0.67-9.85 0.17  
  H5 0.36 0.27 3.22 1.34-7.76 0.009  
High CHOL/HDL-C H1 0.21 0.30 1.00 - - 0.08
  H2 0.17 0.12 4.66 0.97-22.38 0.05  
  H3 0.10 0.11 2.05 0.32-13.28 0.45  
  H4 0.11 0.14 1.97 0.29-13.46 0.49  
  H5 0.38 0.28 4.40 1.35-14.32 0.01  
  1. Abbreviation: CHOL, Cholesterol; TG, Triglycerides; HDL-C, High density lipoprotein-cholesterol; LDL-C, Low density lipoprotein-cholesterol; HF, Haplotype frequency
  2. a All abnormal variables defined as age- and gender-specific 90th percentile cut-off point of study variables
  3. b Five common haplotype frequencies of IL-6R rs4845617 G/A, rs4845623 A/G, and rs2229238 C/T (H1: GAC, H2: GAT, H3: GGC, H5: AAC, H6: AAT) at least 5% and H1 as reference group.
  4. c Abnormal lipid includes high TG or low HDL-C