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Table 3 Genotypic frequencies of the ABCA1 V825I polymorphism and serum lipid levels between the Bai Ku Yao and Han populations

From: Genetic variant of V825I in the ATP-binding cassette transporter A1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

Genotype

n

TC (mmol/L)

TG (mmol/L)

HDL-C (mmol/L)

LDL-C (mmol/L)

ApoAI (g/L)

ApoB (g/L)

ApoAI/ApoB

Bai Ku Yao

        

GG

228

4.28 ± 0.79

1.09 (0.80)

1.63 ± 0.39

2.52 ± 0.65

1.30 ± 0.34

0.84 ± 0.21

1.65 ± 0.69

GA

321

4.26 ± 0.82

0.96 (0.61)

1.64 ± 0.41

2.52 ± 0.68

1.28 ± 0.29

0.83 ± 0.22

1.64 ± 0.63

AA

128

4.52 ± 1.26

0.95 (0.61)

1.72 ± 0.45

2.69 ± 1.04

1.33 ± 0.35

0.86 ± 0.26

1.73 ± 0.91

F

-

3.839

4.621

2.073

2.358

1.460

0.663

0.862

P

-

0.022

0.099

0.127

0.095

0.233

0.516

0.423

Male

        

GG

110

4.29 ± 0.80

1.25 (0.91)

1.65 ± 045

2.43 ± 0.68

1.36 ± 0.39

0.82 ± 0.21

1.81 ± 0.86

GA

153

4.26 ± 0.88

1.00 (0.66)

1.67 ± 0.45

2.47 ± 0.73

1.32 ± 0.33

081 ± 021

1.76 ± 0.74

AA

61

4.53 ± 1.62

1.02 (0.68)

1.74 ± 0.56

2.63 ± 1.33

1.40 ± 0.44

0.83 ± 0.30

1.96 ± 1.19

F

-

1.850

4.969

0.974

1.377

1.040

0.081

1.370

P

-

0.159

0.083

0.379

0.254

0.355

0.922

0.256

Female

        

GG

118

4.26 ± 0.80

0.97(0.62)

1.60 ± 0.33

2.59 ± 0.62

1.25 ± 0.26

0.87 ± 0.20

1.50 ± 0.44

GA

168

4.26 ± 0.77

0.94(0.56)

1.62 ± 0.36

2.57 ± 0.63

1.24 ± 0.25

0.85 ± 0.22

1.53 ± 0.47

AA

67

4.50 ± 0.80

0.92(0.49)

1.69 ± 0.31

2.73 ± 0.68

1.27 ± 0.22

0.89 ± 0.20

1.51 ± 0.45

F

-

2.860

0.595

1.530

2.080

0.474

1.150

0.578

P

-

0.059

0.743

0.220

0.126

0.623

0.320

0.560

Han Chinese

        

GG

216

4.77 ± 0.99

1.00 (0.57)

1.92 ± 0.51

2.61 ± 0.72

1.43 ± 0.27

0.89 ± 0.22

1.70 ± 0.58

GA

314

4.71 ± 1.06

1.01 (0.68)

1.90 ± 0.48

2.62 ± 0.81

1.42 ± 0.28

0.89 ± 0.24

1.69 ± 0.57

AA

116

4.63 ± 0.90

1.02 (0.70)

1.78 ± 0.48

2.64 ± 0.67

1.36 ± 0.27

0.90 ± 0.21

1.58 ± 0.51

F

-

0.600

0.682

3.797

0.190

3.650

0.220

1.930

P

-

0.540

0.711

0.023

0.674

0.027

0.800

0.145

Male

        

GG

104

4.77 ± 1.03

1.01 (0.59)

1.89 ± 0.55

2.62 ± 0.73

1.42 ± 0.30

0.90 ± 0.23

1.69 ± 0.68

GA

154

4.59 ± 1.13

1.01 (0.64)

1.80 ± 0.49

2.56 ± 0.86

1.36 ± 0.29

0.87 ± 0.25

1.68 ± 0.61

AA

57

4.50 ± 1.04

1.03 (0.78)

1.71 ± 0.49

2.58 ± 0.72

1.32 ± 0.30

0.88 ± 0.22

1.61 ± 0.59

F

-

1.039

0.062

3.590

0.037

3.020

0.102

0.575

P

-

0.355

0.970

0.029

0.964

0.049

0.903

0.564

Female

        

GG

112

4.72 ± 0.96

0.96 (0.56)

1.94 ± 0.47

2.59 ± 0.71

1.43 ± 0.24

0.89 ± 0.21

1.70 ± 0.48

GA

160

4.83 ± 0.97

1.02 (0.77)

1.99 ± 0.45

2.68 ± 0.75

1.43 ± 0.26

0.91 ± 0.22

1.72 ± 0.53

AA

59

4.76 ± 0.75

0.99(0.58)

1.85 ± 0.47

2.70 ± 0.63

1.39 ± 0.23

0.93 ± 0.20

1.55 ± 0.42

F

-

0.390

1.182

2.150

0.538

2.640

0.760

2.133

P

-

0.677

0.554

0.118

0.585

0.073

0.469

0.120

  1. TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoAI, apolipoprotein AI; ApoB, apolipoprotein B; ApoAI/ApoB, the ratio of apolipoprotein AI to apolipoprotein B. The value of TG was presented as median (interquartile range). The difference among the genotypes was determined by the Kruskal-Wallis test.