Genetic variant of V825I in the ATP-binding cassette transporter A1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

Cao, Xiao-Li; Yin, Rui-Xing; Wu, Dong-Feng; Miao, Lin; Aung, Lynn Htet Htet; Hu, Xi-Jiang; Li, Qing; Yan, Ting-Ting; Lin, Wei-Xiong; Pan, Shang-Ling

doi:10.1186/1476-511X-10-14

Lipids in Health and Disease

Table 4 Correlative factors for serum lipid parameters between the Bai Ku Yao and Han populations

From: Genetic variant of V825I in the ATP-binding cassette transporter A1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

Lipid parameter	Relative factor	Standardized coefficient	Standard error	t	P
Bai plus Han
TC	Body mass index	0.100	0.150	2.318	0.021
	Age	0.194	0.002	7.234	0.000
	Ethnic group	-1.159	0.050	-6.200	0.001
	Diastolic blood pressure	0.094	0.003	3.400	0.001
	Weight	0.164	0.006	0.164	0.000
	Sex	0.087	0.061	0.087	0.005
TG	Weight	0.216	0.004	7.889	0.000
	Alcohol consumption	0.114	0.042	4.168	0.000
HDL-C	Age	0.211	0.001	8.214	0.000
	Ethnic group	-0.235	0.023	-9.336	0.000
	Alcohol consumption	0.233	0.018	8.246	0.000
	Sex	0.127	0.026	4.541	0.000
	Body mass index	-0.069	0.004	-2.689	0.007
LDL-C	Body mass index	0.093	0.012	2.097	0.036
	Age	0.188	0.001	6.975	0.000
	Alcohol consumption	-0.090	0.029	-3.092	0.002
	Weight	0.209	0.004	4.412	0.000
	Sex	0.084	0.051	2.491	0.013
ApoAI	Age	0.221	0.001	8.308	0.000
	Alcohol consumption	0.230	0.012	8.126	0.000
	Ethnic group	-0.171	0.015	-6.759	0.000
	Diastolic blood pressure	0.061	0.001	2.272	0.023
	Sex	0.057	0.017	2.021	0.044
ApoB	Body mass index	0.237	0.002	8.922	0.000
	Age	0.160	0.000	5.999	0.000
	Ethnic group	-0.087	0.012	-3.393	0.001
	Diastolic blood pressure	0.105	0.001	3.784	0.000
	Sex	0.081	0.012	3.098	0.002
ApoAI/ApoB	Alcohol consumption	0.165	0.023	6.103	0.000
	Body mass index	-0.155	0.006	-5.722	0.000
Bai Ku Yao
TC	Body mass index	0.216	0.014	5.821	0.000
	Age	0.139	0.002	3.730	0.000
	Genotype	0.076	0.048	2.051	0.041
TG	Alcohol consumption	0.197	0.068	4.194	0.000
	Body mass index	0.133	0.016	3.505	0.000
	Sex	-0.154	0.099	-3.099	0.002
	Smoking	-0.125	0.066	-2.485	0.013
HDL-C	Alcohol consumption	0.204	0.022	5.502	0.000
	Age	0.177	0.001	4.765	0.000
LDL-C	Body mass index	0.219	0.012	5.812	0.000
	Age	0.114	0.002	3.034	0.003
	Alcohol consumption	-0.080	0.042	-2.107	0.035
ApoAI	Alcohol consumption	0.310	0.017	8.602	0.000
	Age	0.167	0.001	4.639	0.000
ApoB	Alcohol consumption	0.287	0.039	7.748	0.000
	Body mass index	-0.153	0.011	-4.138	0.000
ApoAI/ApoB	Body mass index	0.207	0.004	5.463	0.000
	Age	0.102	0.001	2.674	0.008
	Sex	0.106	0.017	2.800	0.005
	Diastolic blood pressure	0.094	0.001	2.365	0.018
Han Chinese
TC	Age	0.254	0.002	6.807	0.000
	Diastolic blood pressure	0.128	0.004	3.264	0.001
	Weight	0.281	0.004	7.109	0.000
	Sex	0.165	0.076	4.387	0.000
TG	Weight	0.278	0.005	7.293	0.000
	Alcohol consumption	0.078	0.060	2.033	0.043
HDL-C	Age	0.260	0.001	7.014	0.000
	Alcohol consumption	0.218	0.023	5.628	0.000
	Sex	0.151	0.039	3.770	0.000
	Weight	-0.100	0.002	-2.606	0.009
	Genotype	-0.088	0.025	-2.444	0.015
LDL-C	Age	0.249	0.002	6.620	0.000
	Weight	0.196	0.005	3.524	0.000
	Alcohol consumption	-0.124	0.035	-3.299	0.001
ApoAI	Age	0.307	0.001	8.091	0.000
	Alcohol consumption	0.170	0.013	4.441	0.000
	Sex	0.169	0.021	4.464	0.000
	Diastolic blood pressure	0.085	0.001	2.231	0.026
	Genotype	-0.071	0.014	-1.988	0.047
ApoB	Body mass index	0.261	0.003	6.957	0.000
	Age	0.228	0.001	6.086	0.000
	Diastolic blood pressure	0.106	0.001	2.732	0.006
ApoAI/ApoB	Body mass index	-0.167	0.007	-4.305	0.000

TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoAI, apolipoprotein AI; ApoB, apolipoprotein B.

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