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Table 4 Association between ApoA1/C3/A5 haplotypes and serum lipid levels in the combined population of males and females

From: Apolipoprotein A1/C3/A5 haplotypes and serum lipid levels

Lipid

Haplotype

G-G-T-C-G

G-G-T-C-A

G-G-C-G-G

G-G-T-G-G

G-G-C-C-A

G-A-T-C-G

Rare Hap

Haplotype global association

-

Frequency

0.26

0.26

0.15

0.13

0.06

0.04

0.09

-

-

-

Frequency (carrier vs

Noncarrier)

462 vs. 568

458 vs. 572

328 vs. 702

236 vs. 794

118 vs. 912

92 vs. 938

62 vs. 968

P

P after

permutation correction

TC

Carrier

4.67 ± 0.05

4.64 ± 0.05

4.78 ± 0.06

4.71 ± 0.07

4.87 ± 0.09

4.40 ± 0.10

4.70 ± 0.08

  

(mmol/L)

Noncarrier

4.70 ± 0.05

4.72 ± 0.05

4.64 ± 0.05

4.68 ± 0.04

4.66 ± 0.04

4.71 ± 0.04

4.69 ± 0.04

  
 

P

0.514

0.159

0.024

0.641

0.021

0.002

0.882

2.05E-04

0.001

TG

Carrier

1.10 (0.07)

1.23 (0.07)

1.38 (0.08)

1.20 (0.09)

1.27 (0.12)

1.73 (0.13)

1.15 (0.16)

  

(mmol/L)

Noncarrier

1.33 (0.07)

1.23 (0.07)

1.16 (0.06)

1.24 (0.06)

1.23 (0.06)

1.19 (0.06)

1.24 (0.06)

  
 

P

0.004

0.121

< 0.001

0.866

0.324

0.426

0.055

1.50E-05

0.001

HDL-C

Carrier

2.15 ± 0.03

2.11 ± 0.03

2.14 ± 0.03

2.14 ± 0.04

2.12 ± 0.05

1.95 ± 0.05

2.02 ± 0.04

  

(mmol/L)

Noncarrier

2.09 ± 0.03

2.12 ± 0.03

2.10 ± 0.02

2.11 ± 0.02

2.11 ± 0.02

2.13 ± 0.02

2.13 ± 0.02

  
 

P

0.049

0.835

0.279

0.350

0.933

< 0.001

0.014

1.56E-06

0.001

LDL-C

Carrier

2.38 ± 0.04

2.37 ± 0.04

2.45 ± 0.04

2.40 ± 0.05

2.52 ± 0.06

2.14 ± 0.07

2.43 ± 0.06

  

(mmol/L)

Noncarrier

2.41 ± 0.04

2.42 ± 0.04

2.37 ± 0.03

2.40 ± 0.03

2.38 ± 0.03

2.42 ± 0.03

2.39 ± 0.03

  
 

P

0.405

0.311

0.085

0.978

0.033

< 0.001

0.561

0.001

0.003

ApoA1

Carrier

1.48 ± 0.01

1.46 ± 0.01

1.46 ± 0.01

1.47 ± 0.01

1.49 ± 0.01

1.41 ± 0.02

1.45 ± 0.01

  

(g/L)

Noncarrier

1.46 ± 0.01

1.47 ± 0.01

1.47 ± 0.01

1.46 ± 0.01

1.46 ± 0.01

1.47 ± 0.01

1.47 ± 0.01

  
 

P

0.025

0.581

0.832

0.272

0.043

< 0.001

0.327

6.97E-05

0.001

ApoB

Carrier

0.90 ± 0.01

0.90 ± 0.01

0.93 ± 0.01

0.91 ± 0.02

0.96 ± 0.02

0.83 ± 0.02

0.94 ± 0.02

  

(g/L)

Noncarrier

0.92 ± 0.01

0.92 ± 0.01

0.90 ± 0.01

0.91 ± 0.01

0.91 ± 0.01

0.92 ± 0.01

0.91 ± 0.01

  
 

P

0.171

0.207

0.029

0.797

0.008

< 0.001

0.062

6.85E-06

0.001

ApoA1/

Carrier

1.72 ± 0.03

1.72 ± 0.03

1.67 ± 0.03

1.70 ± 0.04

1.59 ± 0.05

1.81 ± 0.06

1.65 ± 0.05

  

ApoB

Noncarrier

1.69 ± 0.03

1.69 ± 0.03

1.72 ± 0.03

1.70 ± 0.02

1.72 ± 0.02

1.69 ± 0.02

1.71 ± 0.02

  
 

P

0.357

0.211

0.115

0.975

0.011

0.031

0.173

0.001

0.003

  1. TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B