From: Apolipoprotein A1/C3/A5 haplotypes and serum lipid levels
Lipid | Haplotype | G-G-T-C-G | G-G-T-C-A | G-G-C-G-G | G-G-T-G-G | G-G-C-C-A | G-A-T-C-G | Rare Hap | Haplotype global association | |
---|---|---|---|---|---|---|---|---|---|---|
- | Frequency | 0.26 | 0.26 | 0.15 | 0.13 | 0.06 | 0.04 | 0.09 | - | - |
- | Frequency (carrier vs Noncarrier) | 462 vs. 568 | 458 vs. 572 | 328 vs. 702 | 236 vs. 794 | 118 vs. 912 | 92 vs. 938 | 62 vs. 968 | P | P after permutation correction |
TC | Carrier | 4.67 ± 0.05 | 4.64 ± 0.05 | 4.78 ± 0.06 | 4.71 ± 0.07 | 4.87 ± 0.09 | 4.40 ± 0.10 | 4.70 ± 0.08 |  |  |
(mmol/L) | Noncarrier | 4.70 ± 0.05 | 4.72 ± 0.05 | 4.64 ± 0.05 | 4.68 ± 0.04 | 4.66 ± 0.04 | 4.71 ± 0.04 | 4.69 ± 0.04 |  |  |
 | P | 0.514 | 0.159 | 0.024 | 0.641 | 0.021 | 0.002 | 0.882 | 2.05E-04 | 0.001 |
TG | Carrier | 1.10 (0.07) | 1.23 (0.07) | 1.38 (0.08) | 1.20 (0.09) | 1.27 (0.12) | 1.73 (0.13) | 1.15 (0.16) | Â | Â |
(mmol/L) | Noncarrier | 1.33 (0.07) | 1.23 (0.07) | 1.16 (0.06) | 1.24 (0.06) | 1.23 (0.06) | 1.19 (0.06) | 1.24 (0.06) | Â | Â |
 | P | 0.004 | 0.121 | < 0.001 | 0.866 | 0.324 | 0.426 | 0.055 | 1.50E-05 | 0.001 |
HDL-C | Carrier | 2.15 ± 0.03 | 2.11 ± 0.03 | 2.14 ± 0.03 | 2.14 ± 0.04 | 2.12 ± 0.05 | 1.95 ± 0.05 | 2.02 ± 0.04 |  |  |
(mmol/L) | Noncarrier | 2.09 ± 0.03 | 2.12 ± 0.03 | 2.10 ± 0.02 | 2.11 ± 0.02 | 2.11 ± 0.02 | 2.13 ± 0.02 | 2.13 ± 0.02 |  |  |
 | P | 0.049 | 0.835 | 0.279 | 0.350 | 0.933 | < 0.001 | 0.014 | 1.56E-06 | 0.001 |
LDL-C | Carrier | 2.38 ± 0.04 | 2.37 ± 0.04 | 2.45 ± 0.04 | 2.40 ± 0.05 | 2.52 ± 0.06 | 2.14 ± 0.07 | 2.43 ± 0.06 |  |  |
(mmol/L) | Noncarrier | 2.41 ± 0.04 | 2.42 ± 0.04 | 2.37 ± 0.03 | 2.40 ± 0.03 | 2.38 ± 0.03 | 2.42 ± 0.03 | 2.39 ± 0.03 |  |  |
 | P | 0.405 | 0.311 | 0.085 | 0.978 | 0.033 | < 0.001 | 0.561 | 0.001 | 0.003 |
ApoA1 | Carrier | 1.48 ± 0.01 | 1.46 ± 0.01 | 1.46 ± 0.01 | 1.47 ± 0.01 | 1.49 ± 0.01 | 1.41 ± 0.02 | 1.45 ± 0.01 |  |  |
(g/L) | Noncarrier | 1.46 ± 0.01 | 1.47 ± 0.01 | 1.47 ± 0.01 | 1.46 ± 0.01 | 1.46 ± 0.01 | 1.47 ± 0.01 | 1.47 ± 0.01 |  |  |
 | P | 0.025 | 0.581 | 0.832 | 0.272 | 0.043 | < 0.001 | 0.327 | 6.97E-05 | 0.001 |
ApoB | Carrier | 0.90 ± 0.01 | 0.90 ± 0.01 | 0.93 ± 0.01 | 0.91 ± 0.02 | 0.96 ± 0.02 | 0.83 ± 0.02 | 0.94 ± 0.02 |  |  |
(g/L) | Noncarrier | 0.92 ± 0.01 | 0.92 ± 0.01 | 0.90 ± 0.01 | 0.91 ± 0.01 | 0.91 ± 0.01 | 0.92 ± 0.01 | 0.91 ± 0.01 |  |  |
 | P | 0.171 | 0.207 | 0.029 | 0.797 | 0.008 | < 0.001 | 0.062 | 6.85E-06 | 0.001 |
ApoA1/ | Carrier | 1.72 ± 0.03 | 1.72 ± 0.03 | 1.67 ± 0.03 | 1.70 ± 0.04 | 1.59 ± 0.05 | 1.81 ± 0.06 | 1.65 ± 0.05 |  |  |
ApoB | Noncarrier | 1.69 ± 0.03 | 1.69 ± 0.03 | 1.72 ± 0.03 | 1.70 ± 0.02 | 1.72 ± 0.02 | 1.69 ± 0.02 | 1.71 ± 0.02 |  |  |
 | P | 0.357 | 0.211 | 0.115 | 0.975 | 0.011 | 0.031 | 0.173 | 0.001 | 0.003 |