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Table 5 Correlation between serum lipid parameters and alleles/genotypes in the males and females

From: Apolipoprotein A1/C3/A5 haplotypes and serum lipid levels

Lipid parameter

Risk factor

χ2

P

Odds ratio

95% CI

Male plus female

     

   TC

ApoA5 -1131T>C allele

12.284

0.000

1.704

1.265-2.295

   TG

ApoA5 c.553G>T genotype

5.986

0.014

2.293

1.180-4.460

 

ApoA5 c.457 G>A allele

7.713

0.005

2.243

1.268-3.968

 

ApoA5 -1131T>C allele

6.647

0.010

1.534

1.108-2.123

 

ApoA1 -75bp G>A genotype

5.337

0.021

0.345

0.140-0.851

   HDL-C

ApoA5 c.457 G>A allele

7.595

0.006

16.571

2.250-12.048

   LDL-C

ApoC3 3238C>G genotype

12.001

0.001

2.834

1.572-5.111

   ApoA1

ApoA5 c.553G>T genotype

4.978

0.026

11.297

1.343-5.052

   ApoB

ApoC3 3238C>G genotype

13.034

0.000

1.514

1.209-1.897

Male

     

   TC

ApoA5 -1131T>C genotype

4.910

0.027

1.428

1.042-1.957

   TG

ApoA5 c.553G>T genotype

17.322

0.000

7.990

3.003-21.260

 

ApoA5 c.457 G>A allele

4.097

0.043

2.263

1.026-4.989

 

ApoA5 -1131T>C allele

7.400

0.007

2.590

1.305-5.143

 

ApoC3 3238C>G allele

3.904

0.048

0.503

0.254-0.995

 

ApoA1 -75bp G>A genotype

5.372

0.020

0.240

0.072-0.802

   LDL-C

ApoC3 3238C>G genotype

8.307

0.004

1.886

1.225-2.904

   ApoB

ApoA5 c.457 G>A genotype

4.600

0.032

0.464

0.230-0.936

 

ApoC3 3238C>G genotype

4.284

0.038

2.088

1.040-4.193

   ApoA1/ApoB

ApoC3 3238C>G allele

6.836

0.009

0.354

0.163-0.771

 

ApoA1 -75bp G>A allele

3.939

0.047

6.065

1.023-35.968

Female

     

   TC

ApoA5 -1131T>C allele

19.701

0.000

2.651

1.724-4.078

   TG

ApoC3 3238C>G genotype

26.171

0.000

3.149

2.029-4.887

   ApoB

ApoA5 c.457 G>A allele

7.720

0.005

2.961

1.377-6.368

 

ApoA5 -1131T>C genotype

5.390

0.020

1.600

1.076-2.379

 

ApoC3 3238C>G allele

14.382

0.000

3.403

1.807-6.407

 

ApoA1 -75bp G>A genotype

6.842

0.009

3.043

1.322-7.007

 

ApoA1 -75bp G>A allele

4.409

0.036

0.318

0.109-0.927

   ApoA1/ApoB

ApoA5 -1131T>C genotype

7.771

0.005

6.339

1.730-23.221

 

ApoC3 3238C>G allele

5.542

0.019

13.522

1.546-118.228

 

ApoA1 -75bp G>A genotype

5.519

0.019

14.950

1.566-142.771

 

ApoA1 -75bp G>A allele

7.989

0.005

0.017

0.001-0.287

  1. TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B