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Figure 7 | Lipids in Health and Disease

Figure 7

From: Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors

Figure 7

Effect of phytoceramide on transcriptional activity of PPARα in HEPG2 hepatocytes. HEPG2 cells were transfected with 4 × PPRE reporter plasmid and expression vectors for PPARα and RXR. TK Renilla luciferase reporter was cotransfected for normalizing the transfection efficiency. Following transfection, cells were treated for 24 h with phytoceramide (1, 10 μM). Luciferase assays were performed as described elsewhere. All results are shown as means ± S.D. (n = 3). *P < 0.05, significantly different from the level of vehicle control.

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