Association of the GALNT2 gene polymorphisms and several environmental factors with serum lipid levels in the Mulao and Han populations

Li, Qing; Yin, Rui-Xing; Yan, Ting-Ting; Miao, Lin; Cao, Xiao-Li; Hu, Xi-Jiang; Aung, Lynn Htet Htet; Wu, Dong-Feng; Wu, Jin-Zhen; Lin, Wei-Xiong

doi:10.1186/1476-511X-10-160

Lipids in Health and Disease

Table 3 The GALNT2 rs2144300 and rs4846914 genotypes and serum lipid levels between the Mulao and Han populations

From: Association of the GALNT2 gene polymorphisms and several environmental factors with serum lipid levels in the Mulao and Han populations

SNP	Genotype	n	TC (mmol/L)	TG (mmol/L)	HDL-C (mmol/L)	LDL-C (mmol/L)	ApoA1 (g/L)	ApoB (g/L)	ApoA1/ ApoB
GALNT2 rs2144300
Mulao	CC	491	5.06 ± 1.39	1.15(0.84)	1.74 ± 0.42	2.97 ± 0.96	1.35 ± 0.39	0.99 ± 0.55	1.58 ± 0.77
	CT	244	5.05 ± 1.16	1.05(0.83)	1.77 ± 0.43	2.97 ± 0.92	1.35 ± 0.40	0.96 ± 0.54	1.67 ± 0.81
	TT	40	5.20 ± 1.01	0.92(0.92)	1.73 ± 0.38	3.11 ± 0.96	1.32 ± 0.40	0.97 ± 0.47	1.51 ± 0.58
	F	-	0.542	6.874	0.505	1.037	0.115	0.024	0.947
	P	-	0.582	0.032	0.603	0.355	0.892	0.976	0.388
Mulao/male	CC	208	5.12 ± 1.42	1.17(1.11)	1.75 ± 0.42	2.86 ± 0.92	1.39 ± 0.41	1.05 ± 0.64	1.56 ± 0.67
	CT/TT	102	5.39 ± 0.97	1.12(1.20)	1.73 ± 0.42	3.06 ± 0.86	1.37 ± 0.35	1.10 ± 0.62	1.46 ± 0.60
	F	-	3.107	-0.118	0.000	1.859	0.003	0.721	0.931
	P	-	0.079	0.906	0.986	0.174	0.959	0.397	0.335
Mulao/female	CC	283	5.02 ± 1.38	1.14 (0.65)	1.72 ± 0.42	3.06 ± 0.98	1.32 ± 0.37	0.95 ± 0.48	1.61 ± 0.84
	CT/TT	182	4.89 ± 1.20	0.99(0.60)	1.79 ± 0.44	2.95 ± 0.96	1.33 ± 0.42	0.88 ± 0.47	1.75 ± 0.84
	F	-	0.354	-2.851	0.540	0.127	0.091	0.876	1.224
	P	-	0. 552	0.004	0.463	0.722	0.763	0.350	0.269
Han	CC	447	4.97 ± 1.02	1.00 (0.90)	0.73 ± 0.60	2.83 ± 0.86	1.32 ± 0.24	0.84 ± 0.20	1.64 ± 0.46
	CT	232	5.05 ± 1.27	1.07(0.91)	1.73 ± 0.44	2.90 ± 0.96	1.36 ± 0.28	0.85 ± 0.22	1.68 ± 0.51
	TT	20	4.89 ± 1.51	1.10(1.12)	1.79 ± 0.42	3.28 ± 0.67	1.41 ± 0.36	0.93 ± 0.15	1.57 ± 0.52
	F	-	1.452	0.394	0.403	0.309	2.191	1.715	3.572
	P	-	0.235	0.821	0.668	0.734	0.113	0.181	0.029
Han/male	CC	158	5.25 ± 0.96	1.32(1.17)	1.61 ± 0.42	3.01 ± 0.81	1.31 ± 0.26	0.93 ± 0.20	1.47 ± 0.41
	CT/TT	108	5.21 ± 1.32	1.09 (0.93)	1.71 ± 0.42	2.87 ± 0.92	1.40 ± 0.30	0.89 ± 0.20	1.64 ± 0.47
	F	-	0.120	-2.085	4.795	1.156	6.432	4.478	13.073
	P	-	0.729	0.040	0.029	0.283	0.012	0.035	0.000
Han/female	CC	289	4.81 ± 1.02	0.91(0.78)	1.79 ± 0.66	2.75 ± 0.87	1.32 ± 0.24	0.80 ± 0.19	1.73 ± 0.46
	CT/TT	144	4.89 ± 1.25	1.06(0.95)	1.75 ± 0.46	2.96 ± 0.97	1.33 ± 0.27	0.84 ± 0.23	1.70 ± 0.54
	F	-	1.879	-1.683	1.212	7.387	0.043	5.929	1.424
	P	-	0.171	0.092	0.272	0.007	0.836	0.018	0.233
GALNT2 rs4846914
Mulao	GG	365	5.03 ± 1.18	1.12(0.83)	1.75 ± 0.43	2.99 ± 0.89	1.36 ± 0.38	0.99 ± 0.54	1.58 ± 0.61
	GA	250	5.02 ± 1.11	1.07(0.84)	1.76 ± 0.44	2.96 ± 0.86	1.32 ± 0.43	0.95 ± 0.52	1.64 ± 0.77
	AA	34	5.40 ± 0.84	1.05(0.79)	1.72 ± 0.37	3.27 ± 0.88	1.32 ± 0.38	1.05 ± 0.49	1.42 ± 0.59
	F	-	1.810	1.253	0.089	1.911	0.787	0.343	1.430
	P	-	0.164	0.535	0.915	0.149	0.456	0.710	0.240
Mulao/male	GG	159	4.97 ± 1.02	1.16(1.18)	1.75 ± 0.46	2.86 ± 0.79	1.38 ± 0.43	1.00 ± 0.59	1.58 ± 0.65
	GA/AA	101	5.23 ± 0.97	1.21(1.04)	1.74 ± 0.41	3.08 ± 0.78	1.37 ± 0.39	1.05 ± 0.57	1.53 ± 0.70
	F	-	5.626	-0.553	0.012	4.170	0.007	0.305	0.108
	P	-	0.018	0.580	0.913	0.042	0.935	0.582	0.743
Mulao/female	GG	206	5.08 ± 1.29	1.12(0.62)	1.75 ± 0.40	3.09 ± 0.95	1.35 ± 0.34	0.98 ± 0.50	1.57 ± 0.57
	GA/AA	183	4.93 ± 1.14	1.02(0.71)	1.77 ± 0.44	2.96 ± 0.91	1.29 ± 0.44	0.91 ± 0.48	1.66 ± 0.80
	F	-	1.434	-1.597	0.117	1.419	2.219	0.839	0.530
	P	-	0. 232	0.110	0.773	0.234	0.137	0.360	0.467
Han	GG	418	4.97 ± 1.01	1.00(0.80)	1.70 ± 0.40	2.85 ± 0.86	1.31 ± 0.24	0.84 ± 0.19	1.63 ± 0.45
	GA	230	5.01 ± 1.15	1.06(0.95)	1.80 ± 0.72	2.84 ± 0.86	1.37 ± 0.26	0.84 ± 0.20	1.71 ± 0.50
	AA	32	5.16 ± 1.34	1.40(1.22)	1.62 ± 0.40	3.41 ± 0.72	1.32 ± 0.31	0.96 ± 0.17	1.43 ± 0.47
	F	-	0.261	2.716	3.415	4.060	2.658	3.255	3.901
	P	-	0.770	0.257	0.033	0.018	0.071	0.039	0.021
Han/male	GG	151	5.23 ± 0.95	1.16(1.05)	1.63 ± 0.38	3.00 ± 0.81	1.32 ± 0.23	0.92 ± 0.20	1.50 ± 0.41
	GA/AA	98	5.19 ± 1.38	1.15(1.23)	1.67 ± 0.45	2.85 ± 0.93	1.40 ± 0.33	0.89 ± 0.21	1.63 ± 0.51
	F	-	0.136	-0.149	0.253	0.532	2.429	0.762	3.096
	P	-	0.713	0.881	0.615	0.467	0.120	0.384	0.080
Han/female	GG	267	4.83 ± 1.02	0.96(0.73)	1.74 ± 0.41	2.77 ± 0.88	1.31 ± 0.24	0.80 ± 0.18	1.71 ± 0.45
	GA/AA	164	4.94 ± 1.03	1.04(0.95)	1.84 ± 0.79	2.94 ± 0.82	1.34 ± 0.21	0.84 ± 0.19	1.70 ± 0.50
	F	-	0.247	-1.122	2.904	1.735	1.389	0.684	0.575
	P	-	0.619	0.262	0.089	0.188	0.239	0.409	0.449

SNP, single nucleotide polymorphism; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B;
The values of triglyceride were presented as median (interquartile range). The difference among the genotypes was determined by the Kruskal-Wallis test or the Wilcoxon-Mann-Whitney test.

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