Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats

Table 3 Effect of diets on plasma lipid profile and hepatic lipid content in rats

	STD	HC	HC+11S	HC+ROS	HC+11S+ ROS
Plasma
TC (mmol/L)	1.56 ± 0.07^b	4.24 ± 0.45ª	3.77 ± 0.41ª	3.14 ± 0.12ª	4.33 ± 0.40ª
HDL-C (mmol/L)	0.78 ± 0.03^b	0.82 ± 0.06^b	1.04 ± 0.04ª	0.73 ± 0.04^b	0.73 ± 0.08^b
non-HDL-C (mmol/L)	0.78 ± 0.04^b	3.42 ± 0.47ª	2.74 ± 0.4ª	2.43 ± 0.16ª	3.57 ± 0.42ª
TG (mmol/L)	0.48 ± 0.02^b	1.09 ± 0.12ª	0.85 ± 0.11ª	0.84 ± 0.07ª	0.81 ± 0.08ª
Liver
TC (μmol/g)	7.15 ± 0.34^d	57.66 ± 1.06^b	54.97 ± 2.12^b	36.15 ± 2.12^c	76.66 ± 2.12ª
TG (μmol/g)	14.52 ± 0.91^c	58.77 ± 3.97ª	46.48 ± 4.06^b	41.35 ± 2.43^b	46.74 ± 3.08^b
Atherogenic index	1.01 ± 0.05^c	4.62 ± 0.87^ab	2.67 ± 0.38^bc	3.49 ± 0.42^ab	5.06 ± 0.81^a

STD = standard diet, AIN-93 Composition; HC = hypercholesterolemic diet: AIN-93 plus 1 g/100 g cholesterol and 0.5 g/100 g cholic acid; HC+11S = HC diet + glycinin (300 mg/kg/day); HC+ROS = HC diet + rosuvastatin (10 mg/kg/day); HC+11S+ROS = HC diet + glycinin (300 mg/kg/day) and rosuvastatin (10 mg/kg/day). Values are represented as mean ± SEM. TC = total cholesterol; HDL-C = high density lipoprotein; non-HDL-C = difference between TC and HDL-C; TG = triglycerides; atherogenic index = non-HDL-C/HDL-C. Different superscript letters in the same row indicate a significant difference (p < 0.05) between experimental groups.

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