Apolipoprotein ε4 polymorphism does not modify the association between body mass index and high-density lipoprotein cholesterol: a cross-sectional cohort study

Table 3 Adjusted mean (± standard error, SE) high-density lipoprotein cholesterol in each category of body mass index(BMI), by ε4 carrier status (top section) and parameter estimates ± SE and p-values for continuous BMI and continuous BMI × ε4 carrier status (bottom section).

	n	ε4 Carriers	n	ε4 Non-carriers	Overall cohort
HDL ^a , mg/dL, mean ± SE*					Parameter estimate(SE)	p-value
BMI ≤ 25 kg/m²*	112	51.2 ± 0.97	295	53.6 ± 0.62
25 < BMI ≤ 30 kg/m²	162	45.0 ± 0.75	403	51.3 ± 0.49
BMI ≥ 30 kg/m²	123	41.6 ± 0.93	307	45.0 ± 0.62
P-value for trend		< 0.0001		< 0.0001
BMI
Adjusted for age and carrier status					-0.69(0.07)	< 0.0001
Adjusted for age, carrier status, and interaction					-0.70(0.08)	< 0.0001
Multivariate-adjusted^b					-0.75(0.07)	< 0.0001
Continuous BMI × carrier term
Adjusted for age, BMI, and carrier status					0.02(0.14)	0.90
Multivariate-adjusted^b					0.10(0.12)	0.39

*BMI = Body Mass Index; HDL = high-density lipoprotein cholesterol; mg/dL = milligrams/deciliter; kg/m² = kilograms/meters-squared
^┼Multivariate-adjusted estimates for HDL are adjusted for age, gender, categorized BMI, current smoker (yes/no), alcohol intake(≥ 2 beverages daily, yes/no), monounsaturated fat intake in grams, polyunsaturated fat intake in grams, minutes of exercise daily, angina, coronary heart disease, stroke, cancer, hypertension, diabetes mellitus, and low-density lipoprotein cholesterol
^bMultivariate-adjusted parameter estimates are adjusted for age, gender, continuous BMI, ε4 carrier status, continuous BMIxε4 carrier interaction, current smoker (yes/no), alcohol intake (≥ 2 beverages daily, yes/no), monounsaturated fat intake in grams, polyunsaturated fat intake in grams, minutes of exercise daily, angina, coronary heart disease, stroke, cancer, hypertension, diabetes mellitus, and LDL.

ISSN: 1476-511X