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Table 3 Mean NMR lipoprotein particle size and number in women stratified by baseline triglyceride status.

From: High-fat meal effect on LDL, HDL, and VLDL particle size and number in the Genetics of Lipid-Lowering drugs and diet network (GOLDN): an interventional study

 

Normal Triglycerides

Hyper-Triglyceridemic

p-values

 

0 Hr

3.5 Hr

6 Hr

0 Hr

3.5 Hr

6 Hr

Triglyceride Status

Time

Triglyceride status × time

LDL particle No., nmol/L

1087 (19)

1061 (18)

1077 (19)

1550 (26)

1508 (26)

1531 (26)

< 0.0001

< 0.0001

0.2495

IDL particles, nmol/L

22 (2)

38 (2)

41 (2)

58 (3)

70 (3)

67 (3)

< 0.0001

< 0.0001

0.0155

Large LDL particles, nmol/L

457 (13)

486 (13)

526 (13)

426 (17)

481 (17)

522 (18)

0.1334

< 0.0001

0.0029

Small LDL particles, nmol/L

614 (20)

547 (19)

521 (19)

1054 (28)

943 (27)

926 (28)

< 0.0001

< .0001

0.0076

LDL particle size, nm

21 (0.03)

21 (0.03)

21 (0.03)

21 (0.05)

21 (0.05)

21 (0.05)

< 0.0001

< 0.0001

0.007

HDL particle No., μmol/L

33 (0.3)

32 (0.3)

32 (0.3)

35 (0.4)

34 (0.4)

35 (0.4)

0.0576

< 0.0001

0.0008

Large HDL particles, μmol/L

8 (0.2)

8 (0.2)

9 (0.2)

6 (0.3)

5 (0.3)

5 (0.3)

< 0.0001

0.0581

< 0.0001

Medium HDL particles, μmol/L

5 (0.2)

8 (0.2)

10 (0.3)

5 (0.3)

8 (0.3)

10 (0.4)

0.7465

< 0.0001

0.026

Small HDL particles, μmol/L

20 (0.3)

16 (0.3)

13 (0.3)

24 (0.4)

20 (0.4)

19 (0.5)

< 0.0001

< 0.0001

0.0002

HDL particle size, nm

9 (0.02)

9 (0.02)

9 (0.02)

9 (0.03)

9 (0.03)

9 (0.03)

< 0.0001

< 0.0001

< 0.0001

VLDL particle No., nmol/L

37 (1)

40 (1)

31 (1)

84 (2)

76 (2)

75 (2)

< 0.0001

< 0.0001

< 0.0001

Large VLDL particles, nmol/L

1 (0.2)

2 (0.2)

2 (0.2)

6 (0.2)

10 (0.3)

8 (0.3)

< 0.0001

< 0.0001

< 0.0001

Medium VLDL particles, nmol/L

15 (0.9)

20 (0.9)

11 (0.9)

39 (1)

41 (1)

36 (1)

< 0.0001

< 0.0001

< 0.0001

Small VLDL particles, nmol/L

20 (0.8)

16 (0.7)

18 (0.7)

35 (1)

23 (1)

28 (1)

< 0.0001

< 0.0001

< 0.0001

Chylomicrons, nmol/L

0.04 (0.004)

0.2 (0.01)

0.2 (0.01)

0.03 (0.005)

0.4 (0.01)

0.4 (0.02)

< 0.0001

< 0.0001

< 0.0001

VLDL particle size, nm

51 (0.4)

54 (0.4)

60 (0.5)

53 (0.6)

60 (0.6)

62 (0.8)

0.0014

< 0.0001

< 0.0001

  1. Adjustment variables include field center, age, waist circumference, smoker, diabetes.
  2. HDL = high-density lipoprotein; IDL = intermediate-density lipoprotein; LDL = low-density lipoprotein; NMR = nuclear magnetic resonance spectroscopy; VLDL = very low-density lipoprotein.
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Lipids in Health and Disease

ISSN: 1476-511X