Dietary saturated and monounsaturated fats protect against acute acetaminophen hepatotoxicity by altering fatty acid composition of liver microsomal membrane in rats

Table 2 Fatty acid composition of phospholipids in liver microsomal membrane¹

Fatty Acid	Corn oil	Olive oil	Beef tallow
		μmole %
C14:0	0.25 ± 0.10	0.42 ± 0.17	0.25 ± 0.15
C16:0	19.9 ± 0.86	21.4 ± 2.39	23.8 ± 2.35
C16:1n-7	0.25 ± 0.20^b*	1.19 ± 1.36^a	0.95 ± 0.24^a
C18:0	25.6 ± 3.22	23.5 ± 2.14	23.9 ± 2.63
C18:1n-9	3.27 ± 2.30^b**	9.46 ± 3.97^a	6.91 ± 0.51^a
C18:1n-7	1.04 ± 0.54	2.67 ± 0.63	1.93 ± 0.59
C18:2n-6	13.5 ± 1.08^a**	7.12 ± 0.39^b	7.20 ± 0.56^b
C18:2/C18:1²	3.13 ± 0.62^a***	0.63 ± 0.16^b	0.82 ± 0.09^b
C18:3n-3	0.47 ± 0.53	0.26 ± 0.28	0.03 ± 0.07
C20:4n-6	28.0 ± 1.40	26.6 ± 2.61	26.1 ± 1.87
DBI³	1.450	1.347	1.286

¹Values are means ± S.D.
²The ratios of linoleic acid to oleic acids
³The double bond index (DBI) equals the sum obtained by multiplying the fraction of each fatty acid times the number of double bonds contained and adding the total together [10].
* p < 0.05, ** p < 0.005, *** p < 0.0001 compared with beef tallow and olive oil fed groups by Kruskal-Wallis test. Different superscripts for each fatty acid mean significantly different levels among groups.

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