Simulated reduction (%) in LDL cholesterol after treatment with different doses of atorvastatin. The solid line shows the fit to the model and symbols represent experimental data from Berry et al.  Values for the Michaelis-Menten parameters are: effective maximum LDL cholesterol reduction (R
) = 0.544 and half maximum reduction statin dose (SP, 1/2) = 6.7 mg/d. The dashed lines show the 5% and 95% uncertainty range in reduction obtained by correlated sampling (correlation coefficient ρ = 0.88) of R
and SP, 1/2from their covariance matrix.