Figure 3

Simulated reduction (%) in LDL cholesterol after treatment with different doses of atorvastatin. The solid line shows the fit to the model and symbols represent experimental data from Berry et al. [21] Values for the Michaelis-Menten parameters are: effective maximum LDL cholesterol reduction (R _{P, max} ) = 0.544 and half maximum reduction statin dose (S_{P, 1/2}) = 6.7 mg/d. The dashed lines show the 5% and 95% uncertainty range in reduction obtained by correlated sampling (correlation coefficient ρ = 0.88) of R _{P, max} and S_{P, 1/2}from their covariance matrix.