Figure 4

Simulated reduction (%) in LDL cholesterol after treatment with different doses of phytosterols/-stanols. The solid line shows the fit to the model and symbols represent experimental data from Demonty et al. [22] Values for the Michaelis-Menten parameters are: effective maximum LDL cholesterol reduction (R _{U, max} ) = 0.221 and half maximum reduction phytosterol/-stanol dose (PS_{U, 1/2}) = 1.78 mg/d. The dashed lines show the 5% and 95% uncertainty range in reduction obtained by correlated sampling (correlation coefficient ρ = 0.98) of R _{U, max} and PS_{U, 1/2}from their covariance matrix.