Skip to main content

Table 1 Model variables and abbreviations used in the study

From: Modelling approach to simulate reductions in LDL cholesterol levels after combined intake of statins and phytosterols/-stanols in humans

Model variable Abbreviation
Endogenously produced cholesterol P C
Dietary cholesterol intake I C
External daily statin dose S
External daily free phytosterol/-stanol dose PS
(Steady state) concentration of free cholesterol in the liver C
VLDL particles V
Absorbed cholesterol fraction f abs
Fraction of produced VLDL cholesterol that re-enters the liver f back
Association rate of VLDL particles and free cholesterol to VLDL cholesterol k VC
Excretion of cholesterol from the cholesterol pool by bile k bile
Excretion of cholesterol through the formation of bile salts k salts
Reduction in cholesterol pool size R C
Cholesterol pool concentration in absence of statins and phytosterols/-stanols C 0
Endogenous produced cholesterol in absence of statins and phytosterols/-stanols P C,0
Uptake of dietary cholesterol in absence of statins and phytosterols/-stanols U C,0
Absorbed cholesterol fraction in absence of statins and phytosterols/-stanols f abs ,0
Reduction in endogenous cholesterol production R P
Reduction in fraction of cholesterol uptake from the diet R U
Ratio of exponential rates of different cholesterol elimination routes ρ k
VLDL cholesterol production rate P VC
Transformation rate of VLDL cholesterol to LDL cholesterol k VL
(Steady state) VLDL cholesterol concentration VC
Maximum rate of change in (V)LDL cholesterol due to saturated uptake process V max
Michaelis-Menten constant in (V)LDL cholesterol model K M
(Steady state) LDL cholesterol concentration LC
LDL cholesterol production from VLDL cholesterol P LC
Clearance rate of LDL cholesterol through non-saturated process k n
Maximal achievable reduction in endogenous cholesterol production R P, max
Half maximum reduction statin dose S P, 1/2
Maximal achievable reduction in fraction of cholesterol uptake from the diet R U, max
Half maximum reduction phytosterol/-stanol dose PS U, 1/2