Apolipoprotein E mRNA expression in mononuclear cells from normolipidemic and hypercholesterolemic individuals treated with atorvastatin

Table 2 Genotype and allele frequencies of APOE polymorphisms in hypercholesterolemic and normolipidemic individuals.

Genotypes	ε2ε2	ε2ε3	ε2ε4	ε3ε3	ε3ε4	ε4ε4
HC (n = 181)	0.0% (0)	2.8% (5)	0.6% (1)	66.3% (120)	26.5%(48)	3.8% (7)
NL (n = 181)	0.6% (1)	9.4% (17)	5.0% (9)	61.3% (111)	22.7%(41)	1.1% (2)
	χ² = 17.624; 5 df; p = 0.003
Alleles	ε2	ε3	ε4
HC	1.7%	80.9%	17.3%
NL	7.7%	77.4%	14.9%
	χ² = 15.223; 2 df; p < 0.001
	Allele	O.R.	95%C.I.			p-value
	ε3	1.00	--			--
	ε2	0.27	0.08-0.85			0.025
	ε4	1.31	0.76-2.26			0.331

Number of individuals is in parenthesis. HC, hypercholesterolemic; NL, normolipidemic; df, degrees of freedom; O.R., odds ratio; C.I. confidence interval. O.R. values and 95% C.I. were obtained from logistic regression analysis using hypercholesterolemia as dependent variable with gender, ethnics, history of coronary artery disease, age, hypertension, obesity, cigarette smoking, physical activity and alcohol consumption as covariates for the model. Influence of ε2 and ε4 alleles on risk for hypercholesterolemia was accessed comparing with the reference allele ε3.

ISSN: 1476-511X