Apolipoprotein E mRNA expression in mononuclear cells from normolipidemic and hypercholesterolemic individuals treated with atorvastatin

Table 3 Influence of APOE polymorphisms on basal serum lipids in normolipidemic and hipercholesterolemic individuals

Parameter	ε2	ε3	ε4	p-value
*Normolipidemics*	(18)	(111)	(43)	--
Total cholesterol, mg/dL	160 ± 23^a	173 ± 18^b	177 ± 15^b	0.003
LDL cholesterol, mg/dL	81 ± 18^a	99 ± 18^b	105 ± 16^b	< 0.001
HDL cholesterol, mg/dL	65 ± 11^a	57 ± 12^b	56 ± 12^b	0.023
VLDL cholesterol, mg/dL	14 ± 5	17 ± 6	16 ± 5	0.179
Triglycerides, mg/dL	72 ± 25	84 ± 28	80 ± 26	0.179
ApoAI, mg/dL	150 ± 20	140 ± 25	137 ± 31	0.205
ApoB, mg/dL	71 ± 19^a	86 ± 23^b	90 ± 22^b	0.011
*Hypercholesterolemics*	(5)	(120)	(55)	--
Total cholesterol, mg/dL	253 ± 25	271 ± 43	267 ± 31	0.668
LDL cholesterol, mg/dL	166 ± 22	183 ± 39	181 ± 25	0.622
HDL cholesterol, mg/dL	62 ± 18	57 ± 14	56 ± 13	0.679
Triglycerides, mg/dL	133 ± 42	151 ± 71	148 ± 52	0.713
VLDL cholesterol, mg/dL	27 ± 8	30 ± 14	30 ± 10	0.713
ApoAI, mg/dL	140 ± 34	138 ± 29	132 ± 19	0.418
ApoB, mg/dL	128 ± 29	143 ± 28	143 ± 25	0.450

Number of individuals is in parenthesis. Values are expressed as media ± SD and compared by one way ANOVA. HC, hypercholesterolemic; NL, normolipidemic; LDL, low density lipoprotein; HDL, high density lipoprotein; VLDL, very low density lipoprotein; ApoAI, apolipoprotein AI; ApoB, apolipoprotein B. ε2 represent ε2ε2 and ε2ε3 carriers; ε3 symbolize ε3ε3 genotype and ε4 represent ε3ε4 and ε4ε4 individuals. ^{a, b}, different letters at the same line represent statistical significance. Conversion factors to convert to Systeme Internacional (SI) units are 0.02586 for cholesterol (mmol/l), 0.01129 for triglycerides (mmol/l) and 0.01 for apolipoproteins (g/l).

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