Effect of gender on atherosclerotic lesions in the aortic root of 8- to 10-week-old apoE-/- mice fed for 3 months with a high-fat diet. Average aorta thickness is significantly higher in females than males (A). Hematoxylin-eosin stained cross sections at the root of the aorta show remarkable differences in the atherosclerotic lesion between the female and the male mouse (B). Reproduced from Smith et al.  with permission.