Figure 1

Effect of gender on atherosclerotic lesions in the aortic root of 8- to 10-week-old apoE^-/- mice fed for 3 months with a high-fat diet. Average aorta thickness is significantly higher in females than males (A). Hematoxylin-eosin stained cross sections at the root of the aorta show remarkable differences in the atherosclerotic lesion between the female and the male mouse (B). Reproduced from Smith et al. [24] with permission.