Figure 1
From: The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit
ETC-642 reduces endothelial adhesion molecule expression. Panel A: Immunohistochemical staining for ICAM-1 and VCAM-1 in representative thoracic aortic sections from cholesterol-fed NZW rabbits (n = 10 animals/group) infused with either saline, rHDL (8 mg/kg apoA-I) or ETC-642 (30 mg/kg peptide). Panel B: Endothelial expression of ICAM-1 and VCAM-1 were quantified as described in "Materials and Methods". Results are expressed as mean ± SEM. *p < 0.05 and **p < 0.01, compared to saline-infused animals.