The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit

Table 2 Effects of saline, rHDL and ETC-642 infusions on HDL composition

Infusion	Stoichiometry PL^a/UC/CE/TG/Protein (mol/mol)
Saline	27.0 ± 6.8/10.5 ± 1.0/24.0 ± 1.3/1.3 ± 0.2/1.0
rHDL	33.5 ± 6.6/7.9 ± 0.9/21.8 ± 1.1/1.8 ± 0.4/1.0
ETC-642	32.5 ± 10.2/10.8 ± 1.0/22.1 ± 2.0/1.4 ± 0.3/1.0

NZW rabbits (n = 10/group) were maintained on a diet of chow supplemented with 0.2% (w/w) cholesterol for 6 weeks. On days 3 and 5 of the last week of dietary supplementation the animals received two infusions of saline, rHDL (8 mg/kg apoA-I) or ETC-642 (30 mg/kg peptide). Blood was collected at sacrifice and HDL were isolated and their composition determined as described in "Materials and Methods". Results are expressed as mean ± SEM.

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