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Table 1 Incorporation of stable isotopic label into tissue lipid pools in a rabbit 48 hr after an oral dose of PPI-1038.

From: Oral bioavailability of the ether lipid plasmalogen precursor, PPI-1011, in the rabbit: a new therapeutic strategy for Alzheimer's disease

   Plasmalogen Phosphatidylethanolamine
Lipid Tissue P16-G3-D3 (%) G3-D3 (%) D3 (%) G3-D3 (%) D3 (%)
16:0/22:6 Liver 15.9 5.4 10.5 0 13.2
  Kidney 0.1 1.6 18.9 0 14
  Brain 0.02 0.15 0.1 0 1
18:0/22:6 Liver - - 17.9 .84 19.8
  Kidney - - 22.6 .21 9.6
  Brain - - 0.83 0 .57
18:1/22:6 Liver - - 10 20.8 32.9
  Kidney - - 22.3 6.5 20.8
  Brain - - 3.9 2.9 1.3
Free DHA Liver - - 24.7 - -
  Kidney - - 13.6 - -
  Brain - - 3.1 - -
  1. P16, [13C16]palmitate; G3, [13C3]glycerol; D3, [13C3]DHA.
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