From: A clustering analysis of lipoprotein diameters in the metabolic syndrome
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | p-value * | |
---|---|---|---|---|---|---|---|---|---|
N | 200 | 51 | 242 | 237 | 176 | 43 | 7 | 80 | |
α† | .76 (.16; .76-.80) | .80 (.18; .75-.85) | .74 (.18; .72-.76) | .72 (.16; .7-.74) | .74 (.16; .72-.76) | .78 (.17; .73-.83) | .998 (.01; .99-1.00) | .82 (.18; .78-.86) | |
Male, % | 72 | 61 | 60 | 44 | 28 | 19 | 43 | 14 | < 0.0001 |
Age, y | 50.5 (15.0) | 50.9 (14.8) | 50.6 (15.6) | 46.8 (16.7) | 47.5 (16.5) | 41.1 (17.5) | 53.8 (26.1) | 49.7 (16.3) | 0.001 |
Average particle diameter (nm) | |||||||||
VLDL | 53.1 (3.33) | 65.7 (4.9) | 45.6 (3.1) | 53.6 (3.4) | 45.3 (3.0) | 64.2 (5.2) | 98.1 (14.6) | 50.4 (4.1) | < 0.0001 |
LDL | 19.8 (.4) | 20.1 (.6) | 20.4 (.4) | 21.1 (.4) | 21.5 (.4) | 21.7 (.6) | 21.9 (.6) | 22.2 (.4) | < 0.0001 |
HDL | 8.4 (.2) | 8.5 (.2) | 8.6 (.2) | 9.0 (.2) | 9.2 (.2) | 9.4 (.3) | 9.7 (.3) | 9.7 (.3) | < 0.0001 |
Distributions of lipoprotein subfractions (sera concentrations; nmol/L) | |||||||||
VLDL | |||||||||
Small | 39.5 (25.6) | 26.2 (17.3) | 43.5 (23.8) | 27.6 (14.3) | 32.6 (18.2) | 11.1 (8.7) | 4.6 (7.0) | 18.6 (14.2) | < 0.0001 |
Medium | 61.2 (37.5) | 45.6 (51.3) | 44.4 (33.7) | 27.8 (34.0) | 28.1 (24.4) | 8.9 (7.3) | 3.0 (2.3) | 17.7 (14.8) | < 0.0001 |
Large | 7.88 (5.5) | 17.8 (24.6) | 1.8 (1.9) | 3.8 (5.3) | .8 (1.0) | 1.4 (2.3) | .4 (0.4) | .9 (1.3) | < 0.0001 |
LDL | |||||||||
Very small | 1208.4 (400.9) | 1005.9 (359.3) | 886.2 (374.8) | 546.5 (266.4) | 364.7 (227.4) | 298.9 (273.0) | 274.1 (219.1) | 171.0 (156.8) | < 0.0001 |
Small | 1516.6 (462.2) | 1313.9 (466.4) | 1178.7 (410.5) | 745.2 (289.2) | 528.1 (256.7) | 431.0 (333.6) | 351.0 (270.5) | 215.4 (190.0) | < 0.0001 |
Medium small | 308.2 (123.4) | 308.1 (219.5) | 292.5 (212.1) | 198.6 (176.6) | 163.4 (190.9) | 132.1 (174.0) | 76.89 (55.88) | 44.7 (38.15) | < 0.0001 |
Large | 154.6 (116.1) | 238.5 (215.7) | 291.3 (146.7) | 470.8 (189.7) | 560.7 (228.3) | 630.1 (192.4) | 775.99 (271.34) | 746.86 (245.26) | < 0.0001 |
HDL | |||||||||
Small | 25.0 (5.0) | 24.6 (5.4) | 23.7 (4.9) | 20.6 (4.7) | 19.9 (5.1) | 16.4 (4.9) | 16.58 (4.74) | 17.89 (4.51) | < 0.0001 |
Medium | 1.5 (2.7) | 2.7 (3.3) | 1.9 (2.5) | 4.3 (3.9) | 4.0 (4.2) | 5.8 (4.2) | 3.22 (5.22) | 2.43 (3.02) | < 0.0001 |
Large | 3.0 (1.7) | 3.3 (1.9) | 4.6 (1.8) | 6.9 (2.4) | 8.7 (2.3) | 10.0 (2.5) | 11.50 (3.41) | 12.42 (2.44) | < 0.0001 |
Sera lipoprotein particle concentrations (nmol/L) | |||||||||
VLDL | 108.6 (51.4) | 76.4 (54.2) | 80.4 (39.1) | 58.5 (38.7) | 61.2 (29.8) | 28.8 (12.6) | 11.60 (5.21) | 42.19 (20.69) | < 0.0001 |
LDL | 1760.0 (469.2) | 1624.3 (488.8) | 1520.8 (424.6) | 1202.6 (353.6) | 1086.4 (330.6) | 1025.0 (338.5) | 1050.72 (205.79) | 969.10 (304.47) | < 0.0001 |
HDL | 29.1 (5.5) | 30.2 (5.3) | 29.4 (5.7) | 31.0 (5.5) | 31.7 (5.1) | 31.8 (5.5) | 31.89 (6.44) | 32.01 (5.19) | < 0.0001 |