18F-FDG PET/CT scan of a 33-year-old woman with a history of cervical cancer treated with a radical hysterectomy: (A) maximum intensity projection, (B) coronal PET, and (C) coronal PET/CT fusion images showing activated BAT deposits in the posterior neck (PN), supraclavicular (SC), paravertebral (PV) and suprarenal (SR) areas. The hypermetabolic foci in the pelvis were locally recurrent tumors (red arrows) and the neoplastic status score was 3. (D) We used OsiriX 64-bit software with the seeded region growing method (green zone) to obtain the volume of interest (VOI) of activated BAT from the PET images. (E) Color image segmentation based on 3-dimensional clustering was used for display and volume computation. Total metabolic activity (TMA) was defined as the summation of the volume × standardized uptake value (SUV) within the VOIs of the activated BAT deposits.