Table 8 Microarray analyses of RNA after treatment with LPS, LPS + quercetin or quercetin of macrophages from C57BL/6 male mice.
Ageing: | Genes Up-regulated by LPS | |||||
|---|---|---|---|---|---|---|
# | Genes | LPS | LPS + Quercetin | Quercetin | Description | Function |
1 | IL-6 (IFNβ2) | 341.52 | 124.92 | -1.03 | Interleukin 6 (interferon β2) | NF-κB & IL-6 Signaling |
2 | CD40 | 258.44 | 28.36 | 1.40 | CD40 antigen (TNF receptor superfamily mem-5) | Signaling |
3 | IL-1β | 249.03 | 38.18 | 1.02 | Interleukin 1β | NF-κB & IL-6 Signaling |
4 | IFIPT | 186.05 | 136.24 | -4.67 | Interferon induced protein with tetratrocopeptide | Protein |
5 | TRAF1 | 150.74 | 23.09 | -1.97 | TNF receptor associated factor 1 | Signaling |
6 | IL1RA | 125.10 | 113.37 | 34.71 | Interleukin 1 receptor antagonist | Signaling |
7 | CD69 | 105.21 | 13.35 | -3.79 | CD69 antigen (P60, early T-cell activation antigen) | Antigen |
8 | CCND2 | 101.08 | 28.46 | -4.39 | Cyclin D2 | Cell cycle |
9 | VCAM1 | 95.41 | 25.70 | 2.42 | Vascular cell adhesion molecule | Inflammation-linked |
10 | RASGRP1 | 90.88 | 13.71 | -9.18 | Ras guanyl releasing protein 1 | Protein |
11 | CCL8 | 87.72 | 10.33 | 1.19 | Chemokine (C-C motif) ligand 8 | Chemokine |
12 | IL-12β | 70.51 | 5.47 | -4.63 | Interleukin 12β | NF-κB & IL-6 Signaling |
13 | SOCS3 | 62.94 | 24.87 | -5.22 | Suppressor of cytokine signling 3 | Anti-inflammation |
14 | TNF | 54.11 | 47.44 | -1.21 | Tumor necrosis factor | NF-κB & IL-6 Signaling |
15 | SERPIN | 46.27 | 10.85 | -1.64 | Serine or cysteine proteinase inhibitor | Inhibitor |
16 | ABCC | 42.89 | -2.02 | 33.56 | ATP-binding cassette, subfamily C | Protein |
17 | ICAM1 | 41.21 | 8.51 | -3.56 | Intercellular adhesion molecule 1 | Inflammation-linked |
18 | IL-1α | 39.92 | 13.49 | -1.08 | Interleukin 1α | NF-kB & IL-6 Signaling |
19 | UBE2A | 10.41 | 18.06 | 13.26 | Ubiquitin conjugating enzyme E2A | Enzyme |
20 | CNTNA1 | 5.41 | 6.35 | 12.69 | Contactin associated proten1 | Plasma membrane |
21 | ATF7 | 5.05 | 7.14 | 13.68 | Activating transcription factor 7 | Transcriptor |
22 | LRRN6A | 3.42 | 7.98 | 4.36 | Leucine rich repeat neuronal 6A | Enzyme |
Ageing | Genes Down-regulated by LPS | |||||
# | Genes | LPS | LPS + Quercetin | Quercetin | Description | Function |
1 | ABCD2 | -43.36 | -48.92 | -24.78 | ATP-binding cassette, subfamily D member 2 | Protein |
2 | RASGRP3 | -36.19 | -4.43 | -2.46 | RAS guanyl releasing protein 3 (GRP3) | Protein |
3 | PTBP2 | -32.63 | -9.00 | -15.35 | Polypyrimidine tract binding protein 2 | Protein |
4 | IFNGR1 | -28.05 | -1.65 | -9.69 | Interferon gamma receptor 1 | Signaling |
5 | TNP1 | -24.67 | -3.56 | -3.70 | Transition protein 1 | Protein |
6 | PHKA2 | -22.65 | -3.14 | 4.06 | Phosphorylase kinase, alpha 2 (liver) | Enzyme |
7 | UBE2D2 | -22.60 | 1.95 | -22.60 | Ubiquitin conjugating enzyme E2D2 | Enzyme |
8 | HCAP-G | -22.08 | -17.67 | 2.86 | Chromosome condensation protein G | Protein |
9 | 4930503816 | -22.71 | -6.24 | -6.36 | RIKEN cDNA | Enzyme |
10 | NFATC | -5.60 | -3.01 | -41.42 | Nuclear factor of activated T cells cytoplasmic | Transcriptor |