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Table 2 Effect of fenugreek on the body weight, energy intake, tissue weights and plasma

From: Dose-dependent effects, safety and tolerability of fenugreek in diet-induced metabolic disorders in rats

(g)

Ctrl

VL

L

M

H

VH

Body weight gain (g)

500.6 ± 18.5a

491.2 ± 10.2a

486.7 ± 18.5a

463.9 ± 10.2a

480.6 ± 18.5a

408.4 ± 10.2b

EER1 (mg/kJ)

15.6 ± 0.3a

15.3 ± 0.1a

15.6 ± 0.3a

14.6 ± 0.2ab

15.4 ± 0.3a

13.4 ± 0.5b

Liver weight (g)

19.3 ± 1.1

20.0 ± 0.6

18.3 ± 0.7

17.2 ± 0.6

18.0 ± 0.8

17.3 ± 1.0

EWAT2 weight (g)

15.3 ± 0.5a

15.9 ± 0.9a

13.6 ± 0.7ab

14.5 ± 0.7a

16.3 ± 1.4a

10.1 ± 1.0b

IBAT3 weight (g)

0.77 ± 0.04

0.76 ± 0.04

0.74 ± 0.05

0.83 ± 0.05

0.78 ± 0.08

0.55 ± 0.03*

Plasma TG4 (mmol/L)

1.64 ± 0.51

1.98 ± 0.61

2.06 ± 0.29

1.79 ± 0.29

3.63 ± 0.73

2.47 ± 0.46*

Plasma TC5 (mmol/L)

1.50 ± 0.14

1.94 ± 0.14

1.73 ± 0.17

1.83 ± 0.17*

1.72 ± 0.13

1.70 ± 0.12

AST (U/L)

66.2 ± 8.0

76.2 ± 10.6

94.3 ± 21.7

98.5 ± 25.7

67.7 ± 9.1

74.8 ± 8.2

ALT (U/L)

17.3 ± 0.7

21.2 ± 3.2

22.5 ± 3.9

25.0 ± 4.6

19.2 ± 2.4

22.2 ± 1.4

AST/ALT6

1.08 ± 0.11

1.03 ± 0.04

1.14 ± 0.06

1.05 ± 0.08

1.02 ± 0.09

0.95 ± 0.07

  1. Ctrl: Control group, VL: Very low dose of fenugreek group (0.25%), L: Low dose of fenugreek group (1.25%), M: Middle dose of fenugreek group (2.5%), H: High dose of fenugreek group (5.0%), VH: Very high dose of fenugreek group (12.3%). 1EER (mg/kJ) = Body weight gain (mg)/Total food intake (kJ). 2EWAT: Epididymal white adipose tissue. 3IBAT: Interscapular brown adipose tissue. 4TG: Triglyceride. 5TC: Total cholesterol. 6The relative values for Normal rats' data; AST/ALT = AST (U/L)/ALT (U/L)/Normal rats' data. Values are expressed as means ± SEM for 6 rats. Means without a common superscript letter are significantly different, P < 0.05 (ANOVA). Asterisks indicate a difference from Ctrl: P < 0.05 (t-test).