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Table 3 List of inhibitors against enzymes of the mevalonate pathway.

From: The mevalonate pathway in C. elegans

Enzymes Inhibitors Ref
HMG-CoA synthase Hymeglusin [84]
HMG-CoA reductase Statins [6]
Mevalonate kinase Farnesyl thiodiphosphate [85]
Mevalonate diphosphate decarboxylase 6-fluoro-Mevalonate 5-diphosphate [86]
Farnesyl diphosphate synthase Alendronate, Ibandronate,
Pamidronate
[87, 88]
Geranylgeranyl diphosphate synthase Digeranyl bisphosphonate [89]
Farnesyltransferase Manumycin, Gliotoxin [36, 37, 40]