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Table 3 List of inhibitors against enzymes of the mevalonate pathway.

From: The mevalonate pathway in C. elegans

Enzymes

Inhibitors

Ref

HMG-CoA synthase

Hymeglusin

[84]

HMG-CoA reductase

Statins

[6]

Mevalonate kinase

Farnesyl thiodiphosphate

[85]

Mevalonate diphosphate decarboxylase

6-fluoro-Mevalonate 5-diphosphate

[86]

Farnesyl diphosphate synthase

Alendronate, Ibandronate,

Pamidronate

[87, 88]

Geranylgeranyl diphosphate synthase

Digeranyl bisphosphonate

[89]

Farnesyltransferase

Manumycin, Gliotoxin

[36, 37, 40]

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Lipids in Health and Disease

ISSN: 1476-511X