Figure 1

Effect of DLPhtCho and/or POPhtCho on scopolamine-induced impairment of spatial learning and memory. Rats were orally administered with PEG, AA, DHA, PLPhtSer (PS), DLPhtCho (DLPC), POPhtCho (POPC), or DLPhtCho plus POPhtCho (DL & PO) at a dose of 5 mg/kg everyday throughout experiments from 7 days prior to the beginning of water maze test. Saline or scopolamine (1 mg/kg) was intraperitoneally injected 30 min prior to water maze task. (A) Each point represents the mean (± SEM) acquisition latency from consecutive 2 days (n = 6). (B) Each column represents the mean (± SEM) retention latency (n = 6). P values, Dunnett's test. Sham, intraperitoneal injection with saline and oral administration with PEG; Sco treatment + PEG, intraperitoneal injection with scopolamine and oral administration with PEG; Sco treatment + AA, intraperitoneal injection with scopolamine and oral administration with AA; Sco treatment + DHA, intraperitoneal injection with scopolamine and oral administration with DHA; Sco treatment + PS, intraperitoneal injection with scopolamine and oral administration with PLPhtSer; Sco treatment + DLPC, intraperitoneal injection with scopolamine and oral administration with DLPhtCho; Sco treatment + POPC, intraperitoneal injection with scopolamine and oral administration with POPhtCho; Sco treatment + DL & PO, intraperitoneal injection with scopolamine and oral administration with DLPhtCho plus POPhtCho.