Skip to main content
Figure 3 | Lipids in Health and Disease

Figure 3

From: Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes

Figure 3

Dose-dependent repression of SCD1 mRNA levels in rat hepatocytes by hesperetin or nobiletin. Rat hepatocytes were treated with vehicle or 5-150 μM hesperetin or nobiletin for 18-20 h in four independent experiments. mRNAs were quantitated by hybridization (closed symbols) or qRT-PCR (open symbols). Effects of increasing doses of (A) hesperetin or (B) nobiletin on normalized SCD1 mRNA levels are expressed as percent relative to the untreated control. At each flavonoid concentration, n = 3 or 4, and the error bars represent SD. Each experimental condition was compared back to the control by one-way ANOVA with Dunnett's post test using InStat (GraphPad, La Jolla, CA). An asterisk indicates a statistically-significant difference from the untreated control (P ≤ 0.05).

Back to article page

Lipids in Health and Disease

ISSN: 1476-511X