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Table 2 Baseline characteristics of the 455 patients with different apoE alleles

From: Apolipoprotein E epsilon-4 polymorphism is associated with younger age at referral to a lipidology clinic and a poorer response to lipid-lowering therapy

 

Total

Non-ε4 carriers

ε4 carriers

p-value

Age, years

49.2 ± 14.2

50.6 ± 13.8

44.2 ± 14.7

<0.001

Men [n (%)]

267 (58.7%)

156 (58.4%)

159 (59.6%)

0.826

BMI, kg.m-2

28.1 ± 4.7

28.1 ± 4.8

28.1 ± 4.1

0.896

SBP, mmHg

133.8 ± 20.5

135.6 ± 21

127.9 ± 17.6

0.002

DBP, mmHg

83.5 ± 11.7

84.2 ± 11.5

80.9 ± 12.1

0.016

Heart rate, bpm

73.4 ± 12.3

73.5 ± 11.9

73.3 ± 13.8

0.915

TC, mg.dℓ-1

275.9 ± 77.8

277.8 ± 81.3

269.4 ± 64.4

0.338

LDL, mg.dℓ-1

157.7 ± 57.3

157.6 ± 58.5

158.0 ± 53.2

0.956

HDL, mg.dℓ-1

49.6 ± 23.3

49.9 ± 24.9

48.6 ± 17.0

0.618

Triglycerides, mg.dℓ-1

210 (125-389)

218 (127-381)

177 (108-437)

0.5351

Lp(a) (mg.dℓ-1)

15 (6 - 37)

15 (6 - 37)

14 (6 - 36)

0.8151

ApoE (mg.dℓ-1)

6.8 ± 5.9

7.3 ± 6.4

5.3 ± 3.0

0.008

ApoB (mg.dℓ-1)

143.3 ± 46.8

145.7 ± 49.3

135.5 ± 36.5

0.062

ApoA (mg.dℓ-1)

152.4 ± 32.9

154 ± 32.4

146.8 ± 33.9

0.062

ApoB/ApoA

0.98 ± 0.36

1.0 ± 0.4

1.0 ± 0.3

0.593

Creatinine, mg.dℓ-1

0.96 ± 0.49

1.0 ± 0.5

0.9 ± 0.3

0.495

CK (U.ℓ-1)

117.1 ± 123.3

114.1 ± 83.9

127.3 ± 206.2

0.400

  1. 1 Comparisons for natural log-transformed variables. Values are median (interquartile range). BMI: body mass index. SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; LDL: low-density lipoprotein; HDL: high density lipoprotein; Lp(a): lipoprotein (a); Apo: apolipoprotein; CK: creatine kinase.