Apolipoprotein E epsilon-4 polymorphism is associated with younger age at referral to a lipidology clinic and a poorer response to lipid-lowering therapy

Table 4 Follow-up lipid profile of patients

	Total	Non-ε4 carriers	ε4 carriers	p-value
LDL < 130 mg.dℓ^-1 (%)	57.2	61.4	43.2	0.002
LDL < 100 mg.dℓ^-1 (%)	32.4	34.9	23.9	0.052
TC variation (%)	-18.2 ± 2.3	-19.9 ± 2.3	-11.8 ± 2.3	0.003
LDL variation (%)	-16.0 ± 4.7	-17.9 ± 4.9	-9.5 ± 4.3	0.068¹
HDL variation (%)	+11.1 ± 4.3	+11.7 ± 4.7	+7.1 ± 2.6	0.379¹
Triglyceride variation (%)	-10.4 ± 8.5	-11.3 ± 8.7	-4.6 ± 7.8	0.508¹

¹ Mann-Whintey test. TC: total cholesterol; LDL: low-density lipoprotein; HDL: high density lipoprotein; TG: triglyceride.

ISSN: 1476-511X