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Table 2 Comparison of the genotypic and allelic frequencies of PCSK9 E670G polymorphism between Bai Ku Yao and Han Chinese [n (%)]

From: The proprotein convertase subtilisin/kexin type 9 gene E670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

Group n Genotype Allele
   AA AG GG A G
Bai Ku Yao 649 623 (95.99) 26 (4.01) 0 (0.00) 1272 (98.00) 26 (2.00)
Han Chinese 646 588 (91.02) 54 (8.36) 4 (0.62) 1230 (95.20) 62 (4.80)
χ 2 - 14.805 15.447
P - 0.001 0.001
Bai Ku Yao       
   Male 324 309 (95.37) 15 (4.63) 0 (0.00) 633 (97.69) 15 (2.31)
   Female 325 314 (96.62) 11 (3.38) 0 (0.00) 639 (98.92) 11 (1.08)
   χ2 - 0.654 0.641
   P - 0.419 0.423
   Normal TC 549 529 (96.40) 20 (3.60) 0 (0.00) 1078 (98.18) 20 (1.82)
   High TC 100 94 (94.00) 6 (6.00) 0 (0.00) 194 (97.00) 6 (3.00)
   χ2 - 1.874 1.197
   P - 0.171 0.274
   Normal TG 550 526 (95.64) 24 (4.36) 0 (0.00) 1076 (97.82) 24 (2.18)
   High TG 99 97 (97.98) 2 (2.02) 0 (0.00) 196 (98.99) 2 (1.01)
   χ2 - 1.198 0.653
   P - 0.274 0.419
   Normal HDL-C 460 444 (96.52) 16 (3.48) 0 (0.00) 904 (92.27) 16 (7.73)
   Low HDL-C 189 179 (94.71) 10 (5.29) 0 (0.00) 368 (97.35) 10 (2.65)
   χ2 - 1.145 1.121
   P - 0.285 0.290
   Normal LDL-C 488 475 (97.34) 13 (2.66) 0 (0.00) 963 (98.67) 13 (1.33)
   High LDL-C 161 148 (91.93) 13 (8.07) 0 (0.00) 309 (95.96) 13 (4.04)
   χ2 - 9.216 9.027
   P - 0.002 0.003
   Normal ApoAI 546 523 (95.79) 23 (4.21) 0 (0.00) 1069 (97.89) 23 (2.11)
   Low ApoAI 103 100 (97.09) 3 (2.91) 0 (0.00) 203 (98.54) 3 (1.46)
   χ2 - 0.118 0.115
   P - 0.732 0.734
   Normal ApoB 605 581 (95.87) 25 (4.13) 0 (0.00) 1187 (98.10) 25 (1.90)
   High ApoB 43 42 (97.67) 1 (2.33) 0 (0.00) 283 (98.26) 5 (1.74)
   χ2 - 0.338 0.331
   P - 0.561 0.565
   NormalApoAI/ApoB 605 583 (96.36) 22 (3.64) 0 (0.00) 1188 (98.18) 22 (1.82)
   Low ApoAI/ApoB 92 84 (91.30) 8 (8.70) 0 (0.00) 84 (95.45) 4 (4.55)
   χ2 - 1.913 1.874
   P - 0.169 0.171
Han Chinese       
   Male 320 288 (90.00) 32 (10.00) 0 (0.00) 608 (95.00) 32 (5.00)
   Female 326 300 (92.02) 22 (6.75) 4 (1.23) 626 (96.01) 26 (3.09)
   χ2 - 6.042 0.772
   P - 0.492 0.380
   Normal TC 486 442 (90.95) 40 (8.20) 4 (0.85) 928 (98.56) 44 (1.44)
   High TC 160 146 (91.25) 14 (8.75) 0 (0.00) 306 (95.63) 14 (4.37)
   χ2 - 1.357 0.013
   P - 0.507 0.909
   Normal TG 530 480 (90.57) 46 (8.68) 4 (0.75) 1010 (95.28) 50 (4.72)
   High TG 116 108 (93.11) 8 (6.89) 0 (0.00) 224 (96.55) 8 (3.45)
   χ2 - 1.305 0.715
   P - 0.521 0.398
   Normal HDL-C 410 366 (89.27) 42 (10.24) 2 (0.49) 776 (94.63) 44 (4.37)
   Low HDL-C 236 222 (94.07) 12 (5.08) 2 (0.85) 458 (97.03) 14 (2.97)
   χ2 - 4.222 4.024
   P - 0.039 0.045
   Normal LDL-C 458 416 (90.83) 38 (8.30) 4 (0.87) 874 (95.41) 42 (4.59)
   High LDL-C 188 172 (91.49) 16 (8.51) 0 (0.00) 360 (95.75) 16 (4.25)
   χ2 - 1.656 0.068
   P - 0.437 0.795
   Normal ApoAI 594 546 (91.92) 44 (7.41) 4 (0.67) 1136 (95.62) 52 (4.38)
   Low ApoAI 52 42 (80.77) 10 (19.23) 0 (0.00) 92 (90.38) 10 (8.62)
   χ2 - 8.999 5.744
   P - 0.011 0.017
   Normal ApoB 580 530 (91.38) 46 (7.93) 4 (0.69) 1060 (95.34) 100 (4.66)
   High ApoB 66 58 (87.88) 8 (12.12) 0 (0.00) 124 (93.94) 8 (6.06)
   χ2 - 1.178 1.014
   P - 0.411 0.314
   NormalApoAI/ApoB 624 572 (91.67) 48 (7.67) 4 (0.64) 1192 (95.51) 56 (4.49)
   Low ApoAI/ApoB 22 16 (72.73) 6 (27.27) 0 (0.00) 38 (86.36) 6 (13.64)
   χ2 - 10.725 7.787
   P - 0.005 0.005
  1. Normal TC, TC ≤ 5.17 mmol/L, High TC, TC > 5.17 mmol/L; Normal TG, TG ≤ 1.70 mmol/L, High TG, TG > 1.70 mmol/L; Normal HDL-C, HDL-C ≥ 0.91 mmol/L, Low HDL-C, HDL-C < 0.91 mmol/L; Normal LDL-C, LDL-C ≤ 3.20 mmol/L, High LDL-C, LDL-C > 3.20 mmol/L; Normal ApoAI, ApoAI ≥ 1.00 g/L, Low ApoAI, ApoAI < 1.00 g/L; Normal ApoB, ApoB ≤ 1.14 g/L, High ApoB, ApoB > 1.14 g/L; Normal ApoAI/ApoB, ApoAI/ApoB ≥ 1.00, Low ApoA1/B, ApoAI/ApoB < 1.00.