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Table 4 Fitting of NP and MP release data of the optimized formulation (CF6) according to various mathematical models

From: Development and evaluation of controlled porosity osmotic pump for Nifedipine and Metoprolol combination

Model

Parameters used to assess the fit of model

 

R 2

Intercept

K

AIC

 

NP

MP

NP

MP

NP

MP

NP

MP

Zero order

0.9986

0.9994

0.239

0.741

1.48

3.94

5.08

-0.99

First order

-0.9174

-0.9134

2.09

2.09

-0.16

-0.17

-30.32

-29.39

Higuchi

0.9649

0.9671

-11.68

-11.35

25.6

25.84

33.92

33.72

  1. R2 -Goodness of fit.
  2. K - Release rate constant for respective models (K0 in mg/hr, K1 in h-1 and KH in % h1/2 for zero order, first order and Higuchi rate equations respectively).
  3. AIC - Akaike information criterion