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Table 5 Effect of pH on release of NP and MP from CF6 (n = 3)

From: Development and evaluation of controlled porosity osmotic pump for Nifedipine and Metoprolol combination

Time

(h)

Cumulative % release ± SEM

 

NP

MP

 

pH 6.8

pH 1.2

pH change

pH 6.8

pH 1.2

pH change

0

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

2

13.28 ± 0.68

12.60 ± 1.30

13.40 ± 0.71

15.31 ± 1.71

12.52 ± 2.31

12.02 ± 1.35

4

31.81 ± 1.23

29.50 ± 1.89

27.40 ± 1.12

31.71 ± 1.20

28.50 ± 2.44

26.50 ± 2.50

6

44.74 ± 1.50

41.31 ± 2.80

39.08 ± 1.54

45.66 ± 3.12

42.12 ± 2.09

40.82 ± 1.51

8

59.28 ± 1.91

55.90 ± 2.30

53.62 ± 2.31

59.41 ± 2.96

56.95 ± 2.61

53.40 ± 2.97

10

73.15 ± 0.21

70.12 ± 2.67

67.93 ± 3.02

75.27 ± 2.31

72.85 ± 3.42

70.16 ± 2.46

12

88.14 ± 1.10

85.41 ± 1.80

85.20 ± 2.86

89.13 ± 1.90

87.09 ± 3.79

86.40 ± 1.83