Tocotrienols-induced inhibition of platelet thrombus formation and platelet aggregation in stenosed canine coronary arteries

Table 4 Effects of TRF on the concentrations of tocols in canine plasma and platelets¹

Treatments	Total tocopherols (T)²	Total tocotrienols (T3)³	Total T + T3
TRF⁴	Concentrations in μg/mL (ppm)
Plasma (Pre-dose)
Total Tocols⁵	19.72 ± 1.29 ^a (92) ⁶	1.65 ± 0.03 ^a (8)	21.37 ± 1.13 ^a (100) ⁶
Plasma (Post-dose)
Total Tocols	67.38 ± 2.25 ^b (89)	8.56 ± 0.04 ^b (11)	75.94 ± 2.21 ^b (100)
Platelets (Pre-dose)
Total Tocols	7.85 ± 0.62 ^a (67)	3.85 ± 0.23 ^a (33)	11.70 ± 0.48 ^a (100)
Platelets (Post-dose)
Total Tocols	31.44 ± 1.84 ^b (89)	3.84 ± 0.12 ^a (11)	35.28 ± 1.70 ^b (100)

¹Data expressed as means ± SD, n = 3, 3, and 4 respectively, per treatment.
²Total tocopherols = Mixture of α-tocopherol + β-tocopherol + γ-tocopherol + δ-tocopherol.
³Total tocotrienols = Mixture of α-tocotrienol + β-tocotrienol + γ-tocotrienol + δ-tocotrienol
⁴TRF = Tocotrienol Rich Fraction (Mixture of 15% α-tocotrienol + 60% γ-tocotrienol + 25% δ-tocotrienol)
from palm oil (Purified at AMR, Madison, WI).
⁵Tocols = Mixture of α-, β-, γ-, and δ-tocopherols (T) + α-, β-, γ-, and δ-tocotrienols (T3).
⁶Percentages of control values are in parentheses.
^a-bValues in columns with a different superscript letter are significantly different at P < 0.05.

ISSN: 1476-511X