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Table 1 Hamsters were fed with normal chow or high fat diet (HFD) for 10 weeks

From: A novel AMPK activator, WS070117, improves lipid metabolism discords in hamsters and HepG2 cells

 

Control(n = 5)

HFD(n = 8)

 

HDF+WS070117

 

HFD+Simvastatin 2 mg/kg(n = 8)

   

2 mg/kg(n = 8)

6 mg/kg(n = 8)

18 mg/kg(n = 8)

 

TAG (mmol/L)

2.05 ± 0.52

10.98 ± 5.84##

6.52 ± 2.75

5.91 ± 1.98*

4.51 ± 1.88**

6.18 ± 1.28*

TC (mmol/L)

3.95 ± 0.54

9.22 ± 3.87##

7.33 ± 1.84

6.81 ± 1.49

6.11 ± 0.65*

7.73 ± 1.31*

HDL (mmol/L)

1.48 ± 0.25

3.18 ± 1.46#

2.56 ± 0.89

2.45 ± 0.90

2.14 ± 0.26

2.51 ± 0.60

LDL (mmol/L)

2.40 ± 0.36

5.30 ± 2.01##

4.43 ± 0.58

3.97 ± 0.75*

3.16 ± 0.43**

2.51 ± 0.45*

Body weight

136 ± 16.5

168.8 ± 14.7##

166.5 ± 9.3

165.2 ± 15.7

164.5 ± 13.6

166.7 ± 12.6

Liver/Body weight

0.039 ± 0.0054

0.049 ± 0.0046##

0.044 ± 0.0056*

0.044 ± 0.0034*

0.045 ± 0.0023*

0.045 ± 0.0018*

  1. Serum was separated after 8 weeks of WS070117 and Simvastatin treatment at the indicated doses from hamsters fed a high fat diet (HFD). The actual values of mean ± SD from 8 animals (control group, n = 5) are presented. ##P < 0.01, #P < 0.05, as compared to vehicle control; ** P < 0.01, *P< 0.05 as compared to HFD model.