Table 4 Inter-relationship between polymorphisms at -1131T >C of APOA5, S19W of APOA5, C-514T of Hepatic lipase and Pro12Ala of PPARγ with BMI at birth and conditional BMI at 6 months, 2 yrs, 11 yrs and adulthood
Conditional BMI (n) | at birth Mean ± SD | 6 months Mean ± SD | 2 Yrs Mean ± SD | 11Yrs Mean ± SD | Adult Mean ± SD |
|---|---|---|---|---|---|
APOA5 -1131T > C | |||||
TT | 0.006 ± 0.99 | -0.008 ± 0.96 | 0.007 ± 0.97 | -0.019 ± 0.99 | 0.036 ± 0.96 |
TC/CC | 0.024 ± 1.03 | -0.014 ± 1.02 | -0.011 ± 0.99 | 0.053 ± 1.02 | -0.003 ± 1.04 |
P value (Dominant Model) (846/34) | 0.001 | 0.830 | 0.050 | 0.242 | 0.697 |
P value (Recessive Model) (592/288) | 0.803 | 0.935 | 0.802 | 0.312 | 0.578 |
APOA5 S19W | |||||
SS | 0.039 ± 1.00 | 0.003 ± 0.98 | 0.014 ± 1.00 | -0.019 ± 0.98 | 0.012 ± 0.99 |
SW/WW | -0.071 ± 0.92 | 0.146 ± 0.96 | 0.003 ± 1.02 | 0.261 ± 1.01 | -0.038 ± 1.05 |
P value (Dominant Model) (833/2) | 0.848 | 0.185 | 0.835 | 0.551 | 0.173 |
P value (Recessive Model) (772/63) | 0.397 | 0.270 | 0.937 | 0.030 | 0.700 |
HL (C-514T) | |||||
CC | -0.004 ± 1.02 | -0.031 ± 1.00 | 0.020 ± 1.01 | -0.043 ± 0.98 | 0.032 ± 1.01 |
CT/TT | 0.030 ± 0.98 | 0.004 ± 1.01 | -0.050 ± 1.00 | 0.036 ± 1.00 | 0.002 ± 0.96 |
P value (Dominant Model) (897/59) | 0.854 | 0.229 | 0.034 | 0.751 | 0.821 |
P value (Recessive Model) (581/375) | 0.610 | 0.598 | 0.295 | 0.225 | 0.645 |
PPARγ (Pro12Ala) | |||||
Pro12Pro (730) | -0.014 ± 0.98 | 0.004 ± 1.00 | 0.025 ± 0.98 | -0.002 ± 1.00 | 0.018 ± 0.97 |
Pro12Ala/Ala12Ala (186) | 0.058 ± 1.10 | -0.151 ± 0.94 | -0.074 ± 1.04 | -0.026 ± 0.99 | 0.033 ± 1.05 |
P value (Dominant Model) (863/14) | 0.991 | 0.164 | 0.108 | 0.791 | 0.945 |
P value (Recessive Model) (703/174) | 0.394 | 0.065 | 0.241 | 0.782 | 0.853 |