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Table 2 LC-MS-MS analysis of sphingolipid composition in HDL-containing fractions from CCHS serum samples.

From: S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease

Sphingolipid1 Concentration (nM)
  High HDL-C, IHD2 High HDL-C, No IHD2   Low HDL-C, IHD2 Low HDL-C, No IHD2  
  Mean Std Mean Std P value 3 Mean Std Mean Std P value 3
S1P 1362.7 349.6 1643.4 256.2 <0.0001 1220.0 279.6 1569.1 357.0 <0.0001
Sph 10.4 8.5 BDL NA BDL BDL NA
DHSph BDL BDL NA BDL 9.9 22.9 NA
DH-S1P 95.4 49.1 150.5 42.1 <0.0001 82.1 38.1 122.3 45.5 <0.0001
C16-Cer 45.2 60.2 25.6 10.1 <0.0001 BDL 19.7 28.9 NA
DHC16-Cer 9.4 11.5 6.9 3.5 0.5122 BDL BDL NA
C14-Cer BDL BDL NA BDL BDL NA
C18:1-Cer 15.7 5.2 BDL NA BDL BDL NA
C18-Cer 42.2 14.4 41.8 15.9 0.9872 36.9 8.1 34.2 6.6 0.4587
C20:1-Cer 26.9 11.8 BDL NA BDL BDL NA
C20-Cer 103.6 52.3 94.9 37.4 0.8361 43.1 19.7 43.8 17.7 0.9542
C22-Cer 168.5 94.3 208.1 95.8 0.0999 65.4 39.6 79.9 47.7 0.2406
C20:4-Cer 10.1 4.0 BDL NA BDL BDL NA
C22:1-Cer 61.0 32.3 60.7 33.9 0.9851 19.2 8.0 24.9 9.1 0.0223
C24-Cer 1253.8 843.0 2008.3 858.6 <0.0001 708.2 309.9 785.8 392.2 0.8214
C24:1-Cer 699.1 437.5 912.4 348.8 0.0002 320.6 152.5 435.4 163.1 0.0027
C26-Cer 47.1 186.4 38.5 81.0 <0.0001 7.6 3.9 BDL NA
C26:1-Cer 36.5 106.3 27.1 16.2 0.0008 8.4 4.6 8.4 5.4 0.9629
  1. 1Abbrevations used: Sph, sphingosine; DH, dihydro; Cer, ceramide; P, phosphate; BDL, below detection limit, NA, not applicable since at least one group in the pair was below detection limit.
  2. 2Sample sizes are High HDL-C, IHD, n = 53; High HDL-C, no IHD, n = 55; Low HDL-C, IHD, n = 42; Low HDL-C, no IHD, n = 54.
  3. 3p-values are derived from a Tukey's comparison following a one-way ANOVA test conducted at level of significance 0.05.