Table 2 LC-MS-MS analysis of sphingolipid composition in HDL-containing fractions from CCHS serum samples.
Sphingolipid1 | Concentration (nM) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | High HDL-C, IHD2 | High HDL-C, No IHD2 | Â | Low HDL-C, IHD2 | Low HDL-C, No IHD2 | Â | ||||
| Â | Mean | Std | Mean | Std | P value 3 | Mean | Std | Mean | Std | P value 3 |
S1P | 1362.7 | 349.6 | 1643.4 | 256.2 | <0.0001 | 1220.0 | 279.6 | 1569.1 | 357.0 | <0.0001 |
Sph | 10.4 | 8.5 | BDL | NA | BDL | BDL | NA | |||
DHSph | BDL | BDL | NA | BDL | 9.9 | 22.9 | NA | |||
DH-S1P | 95.4 | 49.1 | 150.5 | 42.1 | <0.0001 | 82.1 | 38.1 | 122.3 | 45.5 | <0.0001 |
C16-Cer | 45.2 | 60.2 | 25.6 | 10.1 | <0.0001 | BDL | 19.7 | 28.9 | NA | |
DHC16-Cer | 9.4 | 11.5 | 6.9 | 3.5 | 0.5122 | BDL | BDL | NA | ||
C14-Cer | BDL | BDL | NA | BDL | BDL | NA | ||||
C18:1-Cer | 15.7 | 5.2 | BDL | NA | BDL | BDL | NA | |||
C18-Cer | 42.2 | 14.4 | 41.8 | 15.9 | 0.9872 | 36.9 | 8.1 | 34.2 | 6.6 | 0.4587 |
C20:1-Cer | 26.9 | 11.8 | BDL | NA | BDL | BDL | NA | |||
C20-Cer | 103.6 | 52.3 | 94.9 | 37.4 | 0.8361 | 43.1 | 19.7 | 43.8 | 17.7 | 0.9542 |
C22-Cer | 168.5 | 94.3 | 208.1 | 95.8 | 0.0999 | 65.4 | 39.6 | 79.9 | 47.7 | 0.2406 |
C20:4-Cer | 10.1 | 4.0 | BDL | NA | BDL | BDL | NA | |||
C22:1-Cer | 61.0 | 32.3 | 60.7 | 33.9 | 0.9851 | 19.2 | 8.0 | 24.9 | 9.1 | 0.0223 |
C24-Cer | 1253.8 | 843.0 | 2008.3 | 858.6 | <0.0001 | 708.2 | 309.9 | 785.8 | 392.2 | 0.8214 |
C24:1-Cer | 699.1 | 437.5 | 912.4 | 348.8 | 0.0002 | 320.6 | 152.5 | 435.4 | 163.1 | 0.0027 |
C26-Cer | 47.1 | 186.4 | 38.5 | 81.0 | <0.0001 | 7.6 | 3.9 | BDL | NA | |
C26:1-Cer | 36.5 | 106.3 | 27.1 | 16.2 | 0.0008 | 8.4 | 4.6 | 8.4 | 5.4 | 0.9629 |