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Table 7 De novo synthesis rates after varying periods of deuterium enrichment in rat tissues

From: Organ-Specific Alterations in Fatty Acid De Novo Synthesis and Desaturation in a Rat Model of Programmed Obesity

Source of Data and Species

Tissue

% Deuterium in drinking water

p

(% enrichment

in plasma water)

Days of enrichment

FNS Palmitate (%)

FNS Stearate (%)

Lee et al, AJP, 1994 [34]

Sprague-Dawley

young adult

Liver

4%

2.5

7 days

48.53

39.77

   

2.47

14 days

39.57

31.67

   

2.76

28 days

43.83

32.42

   

2.8

56 days

50.17

37.07

Bassilian et al, AJP, 2002 [35]

Zucker lean

Plasma triglycerides

6%

Not provided

14 days

70.70

61.03

 

Epididymal fat

6%

Not provided

14 days

~18*

~12*

Ajie et al, AJP, 1995 [36]

HRS/J and Sprague-Dawley

Spinal cord

4%

Not provided

56 days

79.35

65.66

  1. * inferred from graph