Skip to main content

Table 1 Total fatty acid composition of PUFA-treated breast cancer cells

From: Effects of n-3 PUFAs on breast cancer cells through their incorporation in plasma membrane

 

MDA-MB-231

MCF-7

 

CTR

AA

EPA

DHA

CTR

AA

EPA

DHA

C:16:0

13.91 ± 2.19

13.48 ± 2.91

6.57 ± 0.91**

8.66 ± 1.25**

16.03 ± 4.06

15.52 ± 1.56

14.7 ± 1.76**

11.14 ± 3.59

C 16:1

1.61 ± 0.85

1.19 ± 0.87

0.87 ± 0.58**

0.77 ± 0.42*

8.25 ± 3.27

2.97 ± 0.86**

3.95 ± 0.54**

2.94 ± 1.53**

C 18:0

17.57 ± 1.97

10.46 ± 2.05*

5.15 ± 1.03**

6.39 ± 1.30**

14.83 ± 1.58

15.73 ± 1.76

10.41 ± 2.49**

9.46 ± 0.89**

C 18:1

26.14 ± 4.74

15.91 ± 4.21*

8.15 ± 0.95**

9.65 ± 1.29**

30.14 ± 2.91

12.12 ± 1.19**

12.21 ± 1.94**

9.77 ± 1.12**

C 18:2

6.05 ± 2.38

3.07 ± 0.65**

2.38 ± 0.17**

2.46 ± 0.32**

4.23 ± 0.73

2.48 ± 1.27**

2.26 ± 0.42**

1.66 ± 0.21**

C 18:3

1.54 ± 4.10

0.68 ± 0.37

0.22 ± 0.16

0.32 ± 0.10**

1.32 ± 0.87

0.96 ± 0.53*

0.59 ± 0.36*

0.63 ± 0.61*

C 20:3

1.64 ± 0.21

1.60 ± 0.10

0.72 ± 0.37**

1.18 ± 0.70*

2.41 ± 0.67

1.28 ± 0.11**

0.67 ± 0.09**

0.78 ± 0.16**

C 20:4 (AA)

14.40 ± 2.92

46.85 ± 10.48*

2.56 ± 0.87**

3.91 ± 0.50**

12.73 ± 2.90

44.26 ± 3.80**

3.13 ± 0.57**

3.20 ± 0.55**

C 20:5 (EPA)

2.42 ± 0.70

0.70 ± 0.23**

38.75 ± 3.52**

1.98 ± 0.43

3.22 ± 0.98

0.74 ± 0.75**

34.16 ± 3.89**

4.90 ± 0.51**

C 22:5 (DPA)

7.04 ± 1.10

3.61 ± 0.44**

33.30 ± 1.83**

2.94 ± 0.62**

1.10 ± 0.71

1.29 ± 0.45

15.80 ± 3.32**

0.96 ± 0.14

C 22:6 (DHA)

7.68 ± 1.55

2.45 ± 0.60**

1.29 ± 0.35**

61.76 ± 3.93**

5.73 ± 2.36

2.65 ± 0.68**

2.12 ± 0.31**

54.55 ± 6.02**

SFA

33.35 ± 5.50

23.94 ± 4.88*

11.76 ± 1.90**

15.05 ± 2.52**

30.86 ± 3.21

31.24 ± 2.89

25.11 ± 3.81**

20.60 ± 4.18**

MUFA

27.74 ± 4.69

17.10 ± 4.61*

9.01 ± 0.82**

10.41 ± 1.06**

38.39 ± 4.36

15.09 ± 1.62**

16.16 ± 2.02**

12.71 ± 2.27**

n-3 PUFA

18.68 ± 3.93

7.44 ± 0.56**

73.56 ± 3.16**

67.00 ± 3.45**

11.37 ± 3.71

5.63 ± 1.58**

52.67 ± 6.24**

61.05 ± 5.96**

n-6 PUFA

22.09 ± 3.15

51.52 ± 9.81**

5.67 ± 1.37**

7.55 ± 0.70**

19.38 ± 3.58

48.03 ± 4.00**

6.06 ± 0.76**

5.64 ± 0.59**

  1. Breast cancer cells were treated with solvent (ethanol) as control, AA (20:4, n-6), EPA (20:5, n-3), and DHA(22:6, n-3).
  2. Fatty acid composition was analyzed and expressed as percentage of total fatty acids (mean ± SD).
  3. Asterisks indicate the significant differences between treated- and control cells (n=10, *P < 0.05; **P < 0.01).